Table 1 Urinary MMP-2 and TIMP-1 levels can differentiate controls from pancreatic malignancies

From: Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies

Variable

Controls ( n =60)

pNET ( n =28)

PDAC ( n =51)

pNET vs control P- value

PDAC vs control P- value

PDAC vs pNET P- value

Gender

      

 Male

34 (57%)

20 (70%)

30 (59%)

0.24

0.85

0.33

 Female

26 (43%)

8 (30%)

21 (41%)

   

Age, years

42±11

56±10

61±11

<0.001a

<0.001a

0.04

uMMP-2, ng ml–1

0.8 (0.2–1.0)

1.7 (1.1–3.3)

1.2 (1.0–1.6)

<0.001a

<0.001a

0.04

uMMP-9, ng ml–1

0.07 (0.00–0.14)

0.11 (0.07–0.15)

0.04 (0.00–0.09)

0.29

0.31

0.02

uTIMP-1, ng ml–1

0.33 (0.12–2.98)

0.67 (0.14–4.30)

4.23 (2.53–13.32)

0.66

<0.001a

<0.001a

  1. Abbreviations: MMP-2=matrix metalloprotease-2; PDAC=pancreatic ductal adenocarcinoma; pNET=pancreatic neuroendocrine tumour; TIMP-1=tissue inhibitor of metalloprotease-1; uMMP= urinary MMP; uTIMP= urinary TIMP.
  2. Biomarker variables are shown as median (interquartile range). Age is presented as mean ±s.d.
  3. Statistically significant (P<0.001, Mann–Whitney U-test).
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