Table 2 Acute toxicity according to treatment group

From: Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option

 

5-FU+MMC ( n =47)

Capecitabine+MMC ( n =58)

 

Type of toxicity

No.

%

No.

%

P -value a

Dermatological toxicity

No toxicity

0

0

0

0

0.035

Grade 1–2

41

87

40

69

 

Grade 3–4

6

13b

18

31

 

Gastrointestinal toxicity

No toxicity

17

36

4

7

1.000

Grade 1–2

29

62

52

90

 

Grade 3–4

1

2

2

3

 

Haematological toxicity

No toxicity

7

15

7

12

1.000

Grade 1–2

37

79

47

83

 

Grade 3–4

3

6

3

6

 

Genitourinary toxicity

No toxicity

34

72

28

48

0.586

Grade 1–2

11

24

29

50

 

Grade 3–4

2

4

1

2

 
  1. Abbreviations: 5-FU=5-fluorouracil; CF-RT=three-dimensional conformal radiotherapy; IMRT=intensity-modulated radiation therapy; MMC=mitomycin C.
  2. aFisher’s exact test for no toxicity or grade 1–2 toxicity vs grade 3–4 toxicity.
  3. bGrade 3–4 dermatological toxicity was equally frequent in 5-FU/CF-RT and 5-FU/IMRT subgroups, with a 13% incidence in both groups.
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