Table 4 Associations of genetic polymorphisms in GSTT1, GSTM1, GSTP1 and TYMS with outcome and toxicity
Clinical response | Overall toxicity | |||||
---|---|---|---|---|---|---|
Polymorphism | PR | CR | P-value a | Grade 0–2 | Grade 3–4 | P-value a |
GSTT1 (deletion) | ||||||
Not NULL | 7 (9%) | 68 (91%) | 0.686 | 55 (72%) | 21 (28%) | 0.065 |
NULL | 3 (14%) | 18 (86%) | 10 (48%) | 11 (52%) | ||
GSTM1 (deletion) | ||||||
Not NULL | 4 (11%) | 34 (89%) | 1.000 | 26 (68%) | 12 (32%) | 0.827 |
NULL | 6 (10%) | 52 (90%) | 38 (66%) | 20 (35%) | ||
GSTP1 313A>G | ||||||
AA | 5 (12%) | 38 (88%) | 0.749 | 33 (77%) | 10 (23%) | 0.124 |
AG or GG | 5 (9%) | 48 (91%) | 32 (60%) | 21 (40%) | ||
TYMS 3’-UTR 6-bp ins/del | ||||||
Ins/Ins | 6 (15%) | 33 (85%) | 0.307 | 25 (64%) | 14 (36%) | 0.657 |
Ins/Del or Del/Del | 4 (7%) | 53 (93%) | 40 (70%) | 17 (30%) | ||
TYMS 5’-UTR VNTR b | ||||||
High expressor | 4 (12%) | 30 (88%) | 0.739 | 28 (82%) | 6 (18%) | 0.025 |
Low expressor | 6 (10%) | 56 (90%) | 37 (60%) | 25 (40%) |