Table 5 Associations of genetic polymorphisms in GSTT1, GSTM1, GSTT1, and TYMS with individual types of toxicity
Dermatological toxicity | Haematological toxicity | Gastrointestinal toxicity | Genitourinary toxicity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grade 0–2 | Grade 3–4 | P -value a | Grade 0–2 | Grade 3–4 | P -value a | Grade 0–2 | Grade 3–4 | P -value a | Grade 0–2 | Grade 3-4 | P -value a | |
GSTT1 | ||||||||||||
Not NULL | 61 (81%) | 14 (19%) | 0.040 | 72 (96%) | 3 (4%) | 0.300 | 73 (97%) | 2 (3%) | 0.527 | 73 (97%) | 2 (3%) | 0.527 |
NULL | 12 (57%) | 9 (43%) | 19 (90%) | 2 (10%) | 20 (95%) | 1 (5%) | 20 (95%) | 1 (5%) | ||||
GSTM1 | ||||||||||||
Not NULL | 29 (76%) | 9 (24%) | 1.000 | 36 (95%) | 2 (5%) | 1.000 | 36 (95%) | 2 (5%) | 0.560 | 38 (100%) | 0 (0%) | 0.275 |
NULL | 44 (76%) | 14 (24%) | 55 (95%) | 3 (5%) | 57 (98%) | 1 (2%) | 55 (95%) | 3 (5%) | ||||
GSTP1 | ||||||||||||
AA | 36 (84%) | 7 (16%) | 0.223 | 42 (98%) | 1 (2%) | 0.376 | 42 (98%) | 1 (2%) | 1.000 | 42 (98%) | 1 (2%) | 1.000 |
AG or GG | 38 (72%) | 15 (28%) | 49 (92%) | 4 (8%) | 51 (96%) | 2 (4%) | 51 (96%) | 2 (4%) | ||||
TYMS 3’-UTR 6-bp ins/del | ||||||||||||
Ins/Ins | 29 (74%) | 10 (26%) | 0.628 | 36 (92%) | 3 (8%) | 0.393 | 38 (97%) | 1 (3%) | 1.000 | 37 (95%) | 2 (5%) | 0.564 |
Ins/Del or Del/Del | 45 (79%) | 12 (21%) | 55 (96%) | 2 (4%) | 55 (96%) | 2 (4%) | 56 (98%) | 1 (2%) | ||||
TYMS 5’-UTR VNTR b | ||||||||||||
High expressor | 30 (88%) | 4 (12%) | 0.075 | 32 (94%) | 2 (6%) | 1.000 | 34 (100%) | 0 (0%) | 0.550 | 34 (100%) | 0 (0%) | 0.550 |
Low expressor | 44 (71%) | 18 (29%) | 59 (95%) | 3 (5%) | 59 (95%) | 3 (5%) | 59 (95%) | 3 (5%) | ||||
