Table 3 The sensitivity and specificity of stool-based miR-18a and miR-221

From: microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma

Stool-based microRNA

microRNA-221

microRNA-18a

Cutoff valuea

48 (best)

68 (80% specificity)

128 (90% specificity)

446 (best)

1845 (80% specificity)

2886 (90% specificity)

Sensitivities, % (95% CI)

CRC

62 (55–68)

52 (45–59)

35 (28–42)

61 (53–68)

46 (39–54)

35 (29–42)

Stage

I+II

44 (33–53)

29 (20–40)

15 (8–26)

61 (54–71)

49 (39–59)

37 (28–27)

III+IV

63 (52–74)

54 (42–65)

28 (19–39)

58 (47–68)

40 (30–51)

31 (21–41)

Location

Proximal

49 (35–63)

41 (28–58)

29 (18–44)

62 (47–75)

46 (32–61)

36 (23–51)

Distal

63 (52–74)

57 (46–69)

35 (25–47)

59 (47–69)

46 (35–58)

37 (26–48)

Rectum

70 (57–84)

55 (42–67)

38 (26–51)

62 (49–74)

48 (36–61)

33 (22–46)

Antibiotic intake

Yes

65 (44–83)

58 (37–77)

33 (26–41)

62 (55–70)

48 (40–55)

35 (17–56)

No

61 (53–68)

51 (43–59)

46 (27–67)

50 (30–70)

38 (20–59)

35 (28–43)

Specificity, % (95% CI)

74 (67–80)

80 (74–86)

90 (85–94)

69 (62–75)

80 (74–86)

90 (85–94)

  1. Abbreviations: CI=confidence interval; CRC=colorectal carcinoma; ROC=receiver operating characteristic.
  2. aCutoff values were expressed as copies of two microRNAs per nanogram of extracted stool total RNA. The cutoff values were selected using ROC curves for reference.
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