Figure 3 | British Journal of Cancer

Figure 3

From: MicroRNA-183 promotes proliferation and invasion in oesophageal squamous cell carcinoma by targeting programmed cell death 4

Figure 3

MiR-183 targets PDCD4 in ESCC cells. (A) Bioinformatics tools were used to predict the binding region of miR-183 in the PDCD4-3′-UTR. (B) Sequence analyses indicated the miR-183 target sequences for different species. (C) miR-183 and si-PDCD4 expression affects PDCD4 protein expression in Eca109 and TE13 cells (D) but does not affect PDCD4 mRNA expression (E) in ESCC cells. (F) Luciferase activity after transfection with wild-type (WT)/mutant-type (MUT) 3′-UTR constructs in PDCD4. Error bars (s.e.m.) were calculated based on triplicate samples (**P<0.005, *P<0.05).

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