Table 5 Research indices in 32 patients in Group 2 (surgery followed by standard chemotherapy)

From: Effect of standard chemotherapy and antiangiogenic therapy on plasma markers and endothelial cells in colorectal cancer

 

Baseline

3 months

6 months

P -value

Circulating endothelial cells (cells ml−1)

12 (0–19)

3 (0–11)

10 (0–12)

0.019a

Endothelial progenitor cells (cells ml−1)

16 (9–44)

0 (0–11)

10 (8–15)

<0.001b

Von Willebrand factor (IU dl−1)

123 (33)

106 (25)

119 (28)

0.08

Soluble E selectin (ng ml−1)

34 (12)

38 (9)

24 (10)

0.007c

VEGF (pg ml−1)

320 (30–1200)

30 (20–287)

30 (21–310)

0.001d

Angiogenin (ng ml−1)

282 (97)

231 (93)

346 (109)

<0.001e

CD34+ve cells (cells ml−1)

781 (417–1315)

839 (583–1212)

686 (361–1056)

0.304

White cell count (x106ml−1)

7.9 (2.2)

5.4 (1.3)

5.8 (2.0)

<0.001d

  1. Data are mean (s.d.) or median (interquartile range). P-value by ANOVA/general linear model/Tukey’s post hoc test.
  2. aP<0.05, baseline to 3-month point.
  3. bP<0.01, baseline to 3 months, P<0.05, 3 months to 6 months.
  4. cP<0.05, 3 months to 6 months.
  5. dP<0.01, baseline to 3 months and to 6 months.
  6. eP<0.05, baseline to 6 months, P<0.01, 3 months to 6 months.
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