Table 6 Research indices in 20 patients in Group 3 (surgery followed by standard chemotherapy and antiangiogenic therapy)

From: Effect of standard chemotherapy and antiangiogenic therapy on plasma markers and endothelial cells in colorectal cancer

 

Baseline

3 months

6 months

P -value

Circulating endothelial cells (cells ml−1)

21 (7–60)

0 (0–13)

11 (7–48)

0.005a

Endothelial progenitor cells (cells ml−1)

21 (10–39)

0 (0–0)

12 (7–32)

<0.001b

Von Willebrand factor (IU dl−1)

121 (30)

122 (26)

122 (15)

0.943

Soluble E selectin (ng ml−1)

26 (8)

22 (15)

29 (12)

0.195

VEGF (pg ml−1)

500 (40–1000)

30 (23–55)

770 (630–1900)

<0.001b

Angiogenin (ng ml−1)

319 (97)

255 (117)

317 (87)

0.074

CD34+ve cells (cells ml−1)

781 (585–1123)

595 (427–1139)

291 (192–535)

0.003c

White cell count (x106ml−1)

6.7 (1.5)

5.1 (1.7)

5.3 (1.4)

0.003d

  1. Data are mean (s.d.) or median (interquartile range).
  2. aP<0.01, baseline to 3 months, P<0.05, 3 months to 6 months.
  3. bP<0.01, baseline to 3 months and baseline to 6 months.
  4. cP<0.01, baseline to 6 months.
  5. dP<0.01, baseline to 3 months, P<0.02, baseline to 6 months.
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