Table 2 ORR and DCR according to PKM2 mRNA expression in the training, validation set and whole population

From: PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer

 

ORR, N (%)

DCR, N (%)

PKM2 mRNA expression

CR+PR

SD+PD

P

CR+PR+SD

PD

P

Training

 High

32 (43.2)

42 (56.8)

0.497

42 (57.7)

32 (42.3)

0.021

 Low

31 (41.9)

43 (58.1)

 

55 (74.3)

19 (25.7)

 

Validation

 High

25 (32.1)

53 (67.9)

0.390

45 (57.7)

33 (42.3)

0.049

 Low

28 (35.4)

51 (64.6)

 

56 (70.9)

23 (29.1)

 

Whole population

 High

57 (37.5)

95 (62.5)

0.590

87 (57.2)

65 (42.3)

0.014

 Low

59 (38.6)

94 (61.4)

 

111 (72.5)

42 (27.5)

 
  1. Abbreviations: CR=complete response; DCR=disease control rate; ORR=objective response rate; PD=progressive disease; PR=partial response; SD=stable disease.
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