Table 4 Screening characteristics of cytological diagnosis and p53 staining of capsule sponge specimens for diagnosis of ESD in the asymptomatic population in Golestan Province, Iran
Endoscopic examination | ||
|---|---|---|
Cytological examination | ESD (all types) | High-grade ESD |
ASC | ||
Sensitivity (95% CI) | 50% (29–71%) | 100% (51–100%) |
Specificity (95% CI) | 99% (96–99%) | 97% (94–98%) |
PPV (95% CI) | 69% (39–90%) | 31% (10–61%) |
NPV (95% CI) | 97% (94–98%) | 100% (98–100%) |
Accuracy (95% CI) | 96% (93–98%) | 97% (94–99%) |
ASC or ASCUS | ||
Sensitivity (95% CI) | 61% (39–80%) | 100% (51–100%) |
Specificity (95% CI) | 92% (88–94%) | 90% (86–93%) |
PPV (95% CI) | 31% (17–79%) | 11% (4–28%) |
NPV (95% CI) | 97% (94–99%) | 100% (98–100%) |
Accuracy (95% CI) | 90% (86–93%) | 90% (86–93%) |
P53 positivity | ||
Sensitivity (95% CI) | 22% (9–45%) | 100% (51–100%) |
Specificity (95% CI) | 89% (85–92%) | 89% (85–92%) |
PPV (95% CI) | 11% (4–28%) | 11% (4–28%) |
NPV (95% CI) | 95% (91–97%) | 100% (98–100%) |
Accuracy (95% CI) | 85% (80–89%) | 89% (85–93%) |
ASC and P53 positivity | ||
Sensitivity (95% CI) | 22% (9–45%) | 100% (51–100%) |
Specificity (95% CI) | 100% (99–100%) | 100% (99–100%) |
PPV (95% CI) | 100% (51–100%) | 100% (51–100%) |
NPV (95% CI) | 95% (92–97%) | 100% (99–100%) |
Accuracy (95% CI) | 95% (92–97%) | 100% (99–100%) |
