Table 2 Associations between colorectal adenoma and colorectal cancer or colorectal neoplasia (both combined) and IBS with adjustment for relevant risk factors using proportion hazards regression models

From: Irritable bowel syndrome and the incidence of colorectal neoplasia: a prospective cohort study with community-based screened population in Taiwan

 

Adenoma

CRC

Colorectal neoplasia

Variable

HR

95% CI

aHR

95% CI

HR

95% CI

aHR

95% CI

HR

95% CI

aHR

95% CI

IBS (Y/N)

1.43

(1.23–1.67)***

1.21

(1.02–1.42)*

1.70

(1.35–2.15)***

1.20

(0.94–1.53)

1.52

(1.34–1.73)***

1.22

(1.07–1.40)**

Age

1.03

(1.02–1.04)***

1.02

(1.01–1.02)***

1.05

(1.04–1.06)***

1.05

(1.04–1.06)***

1.04

(1.03–1.04)***

1.03

(1.02–1.03)***

Gender (M/F)

2.34

(2.02–2.71)***

2.14

(1.80–2.55)***

1.53

(1.22–1.91)**

1.31

(1.04–1.64)*

2.07

(1.84–2.34)***

1.87

(1.62–2.15)***

BMI (⩾30/<30)

1.31

(1.04–1.66)*

1.19

(0.93–1.54)

1.38

(0.96–1.98)

1.27

(0.88–1.84)

1.33

(1.09–1.61)**

1.33

(1.09–1.62)**

CRC family history (Y/N)

1.27

(0.83–1.97)

1.59

(1.03–2.46)*

1.05

(0.50–2.22)

1.54

(0.72–3.27)

1.13

(0.76–1.66)

1.47

(0.99–2.17)

Smoking (Y/N)

1.93

(1.67–2.23)***

—

—

1.06

(0.82–1.37)

—

—

1.65

(1.45–1.87)***

—

—

Drinking (Y/N)

1.83

(1.57–2.12)***

1.36

(1.15–1.61)**

1.05

(0.81–1.37)

—

—

1.57

(1.38–1.79)***

1.25

(1.08–1.44)**

Exercise frequency

Medium/few

1.07

(0.90–1.28)

—

—

0.86

(0.65–1.13)

—

—

1.00

(0.86–1.16)

0.85

(0.73–0.98)*

High/few

1.20

(0.99–1.46)

—

—

1.25

(0.93–1.68)

—

—

1.22

(1.04–1.44)*

0.61

(0.48–0.79)***

Education level

Medium/low

0.75

(0.64–0.88)**

0.79

(0.67–0.94) **

0.61

(0.48–0.79)**

—

—

0.71

(0.62–0.81)***

—

—

High/low

0.59

(0.45–0.78)**

0.58

(0.43–0.78)**

0.43

(0.27–0.69)**

—

—

0.54

(0.43–0.68)***

—

—

Mets (Y/N)

1.38

(1.18–1.60)***

—

—

1.33

(1.04–1.69)*

—

—

1.34

(1.18–1.53)***

—

—

Diabetes (Y/N)

1.01

(0.78–1.31)

—

—

1.87

(1.36–2.59)**

1.43

(1.03–1.99)*

1.24

(1.02–1.52)*

—

—

Hypertension (Y/N)

1.34

(1.16–1.55)***

1.19

(1.02–1.40)*

1.34

(1.07–1.68)*

—

—

1.33

(1.18–1.50)**

—

—

  1. ***P<0.0001, **P<0.01, *P<0.05.
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