Figure 3
From: New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53
Histological analysis of ISA27-treated tumours. (A, B) 14 days from starting treatment, mice were killed and tumours were taken for histological analysis. Cell death and proliferation were evaluated by analysis of cleaved caspase 3 and PCNA levels by immunohistochemistry in paraffin-embedded sections of tumours. ISA27-treated tumours show a dose-dependent increased cleaved caspase 3 levels (B) and reduced cell proliferation (A). Images are representative of three independent experiments.
