Figure 6
From: New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53
Histological analysis of SM13-treated tumours. (A, B) 14 days from starting treatment, mice were killed and tumours were taken for histological analysis. Cell death and proliferation were evaluated by immunohistochemical analysis of cleaved caspase 3 and PCNA levels. SM13-treated tumours show a dose-dependent increase of cleaved caspase 3 levels, marker of apoptosis (B) and reduction of PCNA, marker of cell proliferation (A). Images are representatives of three independent experiments.
