Table1 Organisation of Cullin-Ring ubiquitin Ligases (CRLs)
From: It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer
Cullin-RING E3 ligases | RING | Protein | Adaptor | Substrate recognition |
|---|---|---|---|---|
CRL1/SCF | ROC1/Rbx1 | CUL1 | Skp1 | F-box protein |
CRL2 | ROC1/Rbx1 | CUL2 | EloC/EloB | VHL box |
CRL3 | ROC1/Rbx1 | CUL3 | BTB | BTB |
CRL4 (A/B) | ROC1/Rbx1 | CUL4 | DDB1 | DCAF |
CRL5 | ROC2/Rbx2 | CUL5 | EloC/EloB | SOCS protein |
CRL7 | ROC1/Rbx1 | CUL7 | Skp1 | Fbw8 |
CRL9 | ROC1/Rbx1 | PARC | – | – |
