Table 2 GeneGo enrichment of EGR3-regulated genes

From: Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancer

GeneGo pathway maps

P- value

Gene ontology processes

P- value

Cytokine production by Th17 cells in CF

1.1E−09

Cellular response to chemical stimulus

1.5E−26

Immune response_IL-17 signalling pathways

3.6E−09

Immune system process

2.2E−24

Cytokine production by Th17 cells in CF (mouse)

1.7E−07

Response to chemical stimulus

4.7E−21

Immune response_Histamine H1 receptor

2.3E−06

Response to organic substance

6.8E−21

Androstenedione and testosterone biosynthesis

4.7E−06

Defense response

1.2E−16

Androstenedione and testosterone biosynthesis

5.6E−06

Cellular response to organic substance

1.2E−15

Immune response_IL-1 signalling pathway

1.9E−05

Immune response

1.5E−15

Immune response_Innate immune response to RNA viral infection

2.5E−05

Negative regulation of biological process

7.0E−15

Immune response_Signalling pathway mediated by IL-6 and IL-1

3.6E−05

Response to wounding

1.3E−14

Cell adhesion_Chemokines and adhesion

4.1E−05

Response to cytokine stimulus

1.7E−14

GeneGo process networks

P -value

GeneGo metabolic networks

P- value

Cell adhesion_Platelet-endothelium-leukocyte interactions

6.2E−11

O-hexanoyl-(L)-carnitine pathway

1.8E−03

Development_Regulation of angiogenesis

9.8E−10

Acyl-L-carnitine pathway

1.8E−03

Inflammation_Interferon signalling

5.5E−08

Myristoyl-L-carnitine pathway

2.3E−03

Immune response_Innate immune response to RNA viral infection

1.0E−06

Stearoylcarnitine pathway

2.7E−03

Inflammation_IFN- γ signalling

2.7E−06

6'-sialyllactose pathways and transport

2.9E−03

Immune response_Th17-derived cytokines

5.5E−06

Lyso-Phosphatidylserine pathway

6.7E−03

Inflammation_MIF signalling

6.4E−06

Maltohexaose pathways and transport

9.8E−03

Inflammation_Protein C signalling

1.4E−05

Maltopentaose pathways and transport

1.3E−02

Blood coagulation

2.4E−05

GalNAcbeta1-3Gal pathway

1.3E−02

Inflammation_Innate inflammatory response

2.5E−05

Steroid metabolism_Estrone and Estradiol met.

1.3E−02

  1. Abbreviations: CF=cystic fibrosis; EGR3=Early Growth Response 3; IFN=interferon; IL=interleukin; MIF=migration inhibitory factor; Th17=T helper type 17.
  2. Inflammation-related pathways are highlighted in bold and steroid hormone-related pathways are in italics.
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