Table 4 Univariate and multivariate Cox proportional hazard models to predict survival of patients with locally advanced pancreatic cancer receiving chemotherapy or chemoradiotherapy

From: ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer

 

Univariate analysis

Multivariate analysis

 

HR

95% CI

P -value

HR

95% CI

P -value

Median age, years (63.0)

<63.0/⩾63.0

0.959

0.624–1.474

0.8498

   

Gender

Male/female

0.802

0.519–1.249

0.334

   

PS

0/1 and 2

1.126

0.697–1.819

0.6270

   

Median tumour size, mm (37.4)

<37.4 mm/⩾37.4 mm

1.066

0.665–1.709

0.7902

   

Lymph node metastasis

Negative/positive

1.606

1.008–2.560

0.0463

1.199

0.7654–1.978

0.0740

Location of the tumour

Head/body or tail of pancreas

0.764

0.492–1.185

0.2294

   

CA19-9

<1000/⩾1000 U ml−1

2.354

1.479–3.761

0.0003

2.325

1.416–3.818

0.0009

Actinin-4 IHC

Negative/positive

1.526

0.922–2.528

0.1004

   

ACTN4 FISH

NCN/CNI

2.531

1.394–4.597

0.0023

2.645

1.439–4.861

0.0017

  1. Abbreviations: ACTN4=actinin-4; 95% CI=95% confidence interval; CNI=copy number increase; FISH=fluorescence in situ hybridisation; HR=hazard ratio; IHC=immunohistochemistry; NCN=normal copy number; PS=Eastern Cooperative Oncology Group Performance Status. Bold entries indicate statistically significance.
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