Table 1 Changes in tumour volume, DW-MRI and DCE-MRI parameters between day 0 and day 3 in control and treated TOV-21G and TOV-112D xenografts

Normalised volume (to day 0)

0.26±0.04

−0.15±0.09

<0.001

0.39±0.29

0.17±0.13

0.224^a

Median ADC ( × 10⁻⁶ mm² s⁻¹)

−1.6±50

140±35

<0.001

0.2±13.7

−5.9±26

0.675

ADC skewness

0.2±0.1

−1.0±0.6

0.001 ^a

0.8±2.7

0.0±2.1

0.587

ADC kurtosis

0.6±0.3

−4.5±2.7

0.001 ^a

17.6±38.1

11.5±23.4

0.736

Median K^trans ( × 10⁻³ min⁻¹)^b

−18±15

17±28^c

0.050

−15±8

2±14

0.060

Median v_e ( × 10⁻³)^b

−33±12

131±70^c

0.001

−8±6

19±16

0.002 ^a

Median v_p ( × 10⁻³)^b

−6.4±7.9

14.1±20.4^c

0.091

−0.1±3.8

0.4±5.6

0.875

Median RSI_1 min^b

−0.4±0.4

0.6±0.7^c

0.025

−0.2±0.2

0.1±0.2^d

0.028

Median AUC_1 min a.u.^b

−7.1±6.4

15.4±17.2^c

0.036

−11 .1±7.3

3.8±3.0^d

0.001

FEV_1 min (%)

−14±11

13±15^c

0.011

−14±17

11±16

0.029