Table 2 Cox regression multivariate analysis including LRIG1 staining intensity and known prognostic factors for patients with oropharyngeal cancer
Disease-free survival | Overall survival | |||||
|---|---|---|---|---|---|---|
HR | 95% CI | P -value | HR | 95% CI | P -value | |
LRIG1 intensity | ||||||
Absent | 1 | (ref) | 1 | (ref) | ||
Present | 0.24 | 0.11–0.49 | <0.0001 | 0.49 | 0.26–0.91 | 0.024 |
HPV status | ||||||
Negative | 1 | (ref) | 1 | (ref) | ||
Positive | 0.37 | 0.18–0.75 | 0.006 | 0.26 | 0.15–0.43 | <0.0001 |
CD44 intensity | ||||||
Absent/weak | 1 | (ref) | 1 | (ref) | ||
Medium/strong | 2.88 | 0.99–8.37 | 0.052 | 2.91 | 1.22–6.94 | 0.016 |
Age | ||||||
>67 years | 1 | (ref) | 1 | (ref) | ||
60–67 years | 0.91 | 0.41–2.05 | 0.82 | 0.64 | 0.34–1.21 | 0.17 |
54–60 years | 0.58 | 0.23–1.45 | 0.25 | 0.43 | 0.21–0.89 | 0.022 |
<54 years | 0.30 | 0.085–1.09 | 0.067 | 0.50 | 0.23–1.09 | 0.080 |
Stage | ||||||
I+II | 1 | (ref) | 1 | (ref) | ||
III+IV | 1.41 | 0.55–3.63 | 0.48 | 2.80 | 1.09–7.18 | 0.033 |
Sex | ||||||
Female | 1 | (ref) | 1 | (ref) | ||
Male | 1.08 | 0.52–2.20 | 0.84 | 0.61 | 0.33–1.11 | 0.11 |
Localisation | ||||||
Tonsillar SCC | 1 | (ref) | 1 | (ref) | ||
Base of tongue SCC | 1.06 | 0.20–2.21 | 0.89 | 0.88 | 0.51–1.52 | 0.65 |
