Table 3 Cox regression multivariate analysis including the percentage of LRIG1-positive cells and known prognostic factors for patients with oropharyngeal cancer
Disease-free survival | Overall survival | |||||
|---|---|---|---|---|---|---|
HR | 95% CI | P -value | HR | 95% CI | P -value | |
LRIG1 expression | ||||||
0–25% | 1 | (ref) | 1 | (ref) | ||
26–100% | 0.33 | 0.17–0.65 | 0.001 | 0.49 | 0.30–0.82 | 0.006 |
HPV status | ||||||
Negative | 1 | (ref) | 1 | (ref) | ||
Positive | 0.34 | 0.17–0.69 | 0.003 | 0.27 | 0.16–0.45 | <0.0001 |
CD44 intensity | ||||||
Absent/weak | 1 | (ref) | 1 | (ref) | ||
Medium/strong | 2.81 | 0.97–8.15 | 0.057 | 2.96 | 1.24–7.02 | 0.014 |
Age | ||||||
>67 years | 1 | (ref) | 1 | (ref) | ||
60–67 years | 1.02 | 0.46–2.27 | 0.96 | 0.67 | 0.37–1.24 | 0.203 |
54–60 years | 0.57 | 0.22–1.41 | 0.22 | 0.43 | 0.21–0.88 | 0.020 |
<54 years | 0.29 | 0.082–1.05 | 0.59 | 0.50 | 0.23–1.09 | 0.082 |
Stage | ||||||
I+II | 1 | (ref) | 1 | (ref) | ||
III+IV | 1.29 | 0.50–3.33 | 0.59 | 2.6 | 1.02–6.72 | 0.045 |
Sex | ||||||
Female | 1 | (ref) | 1 | (ref) | ||
Male | 1.05 | 0.51–2.15 | 0.90 | 0.62 | 0.34–1.15 | 0.13 |
Localisation | ||||||
Tonsillar SCC | 1 | (ref) | 1 | (ref) | ||
Base of tongue SCC | 1.29 | 0.62–2.68 | 0.50 | 0.99 | 0.58–1.71 | 0.98 |
