Table 1 Patient characteristics

From: Circulating cell-free AR and CYP17A1 copy number variations may associate with outcome of metastatic castration-resistant prostate cancer patients treated with abiraterone

  

AR

CYP17A1

AR+CYP17A1 combined

 

Characteristics

No. of cases (%)

N

A

P -value

N

A

P -value

NN

AA

AN

P -value

  

No. (%)

No. (%)

 

No. (%)

No. (%)

 

No. (%)

No. (%)

No. (%)

 

Total

53 (100)

37 (100)

16 (100)

–

38 (100)

15 (100)

–

32 (100)

10 (100)

11 (100)

–

Median age, years (range)

74 (57–87)

74 (57–87)

74 (57–85)

0.6787

73 (57–87)

76 (57–86)

0.3139

74 (57–87)

77 (57–85)

72 (61–86)

0.3465

Gleason score

6–7

23 (43)

18 (49)

5 (31)

0.3137

16 (42)

7 (47)

0.6112

14 (44)

3 (30)

6 (55)

0.6232

8–9

29 (55)

19 (51)

10 (63)

 

22 (58)

7 (47)

 

18 (56)

6 (60)

5 (45)

 

Unknown

1 (2)

–

1 (6)

 

–

1 (7)

 

–

1 (10)

–

 

ECOG PS

0–1

46 (87)

35 (95)

11 (69)

0.0209

36 (95)

10 (67)

0.0150

30 (94)

5 (50)

11 (100)

0.0023

2

7 (13)

2 (5)

5 (31)

 

2 (5)

5 (33)

 

2 (6)

5 (50)

–

 

Bone metastases

No

9 (17)

8 (22)

1 (6)

0.2484

7 (18)

2 (13)

1.0000

6 (19)

–

3 (27)

0.2656

Yes

44 (83)

29 (78)

15 (94)

 

31 (82)

13 (87)

 

26 (81)

10 (100)

8 (73)

 

Visceral metastases

No

41 (77)

29 (78)

12 (75)

1.000

30 (79)

11 (73)

0.7220

25 (78)

7 (70)

9 (82)

0.8087

Yes

12 (23)

8 (22)

4 (25)

 

8 (21)

4 (27)

 

7 (22)

3 (30)

2 (18)

 

No. of previous chemotherapeutic lines

1

25 (47)

19 (51)

6 (37.5)

0.3537

20 (53)

5 (33)

0.2049

18 (56)

4 (40)

3 (27)

0.2217

2 or more

28 (53)

18 (49)

10 (62.5)

 

18 (47)

10 (67)

 

14 (44)

6 (60)

8 (73)

 

Median baseline PSA level, ng ml−1 (range)

33.1 (1–1501)

19.7 (1–1501)

152.9 (13.2–1435)

0.0064

21.9 (1–1501)

292.4 (13.8–1435)

0.0006

15.9 (1–1501)

278.3 (13.8–1435)

129.7 (13.2–1083)

0.0007

Median baseline ALP level, mU ml−1 (range)

117 (35–1144)

83 (35–1144)

454 (68–1071)

0.0017

93.5 (36–1144)

383.5 (35–1071)

0.0219

86 (36–1144)

590 (84–1071)

181 (35–1018)

0.0032

Median baseline LDH level, mU ml−1 (range)

201 (48–999)

192 (48–542)

268.5 (121–999)

0.0290

192 (48–961)

250 (166–999)

0.0173

189 (48–542)

287 (203–999)

224.5 (121–961)

0.0154

  1. Abbreviations; ALP=alkaline phosphatase; A=amplified; AR=androgen receptor; CYP17A1=cytochrome P450 17 α-hydrolase; ECOG=Eastern Cooperative Oncology Group; LDH=lactate dehydrogenase; N=normal; PS=performance status; PSA=prostate-specific antigen.
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