Table 4 Association between neutrophil–lymphocyte ratio/platelet–lymphocyte ratio, and mortality in 1435 Asian breast cancer patients using different cutoff values

From: Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer

 

Number of patients

Hazard ratio (95% CI) a

Neutrophil–lymphocyte ratio

3.00

1045

1.00

>3.00

390

1.20 (0.99–1.45)

4.00

1241

1.00

>4.00

194

1.37 (1.08–1.74)b

5.00

1316

1.00

>5.00

119

1.45 (1.08–1.93)b

Platelet–lymphocyte ratio

185

1011

1.00

>185

424

1.25 (1.04–1.52)b

292

1302

1.00

>292

133

1.30 (0.98–1.70)

  1. Abbreviations: CI=confidence interval; HER2=Human epidermal growth factor receptor 2; NLR=neutrophil–lymphocyte ratio; PLR=platelet–lymphocyte ratio.
  2. aHazard ratios for NLR were derived using Cox regression adjusted for age at diagnosis, ethnicity, tumour size, number of positive axillary lymph nodes, distant metastasis, oestrogen/progesterone receptor status, HER2 status, tumour grade, lymphovascular invasion, type of surgery, radiotherapy, neoadjuvant chemotherapy, adjuvant chemotherapy regime, hormone therapy and platelet–lymphocyte ratio. For PLR, a similar Cox model was used, but was instead adjusted for neutrophil–lymphocyte ratio.
  3. bStatistically significant.