Table 2 Personal history of rosacea and risk of incident cancer (1991–2011)

From: Personal history of rosacea and risk of incident cancer among women in the US

 

No Rosacea

Rosacea

Age-adjusted RR

Multivariable-adjusted RR a

Internal malignancies

1 382 634 person-years

64 571 person-years

  

Breast cancer

2998

186

1.07 (0.92–1.24)

1.03 (0.89–1.20)b

Thyroid cancer

331

29

1.54 (1.05–2.26)e

1.59 (1.07–2.36)e

Endometrial cancer

255

11

0.71 (0.38–1.29)

0.66 (0.35–1.22)

Colorectal cancer

215

12

0.87 (0.49–1.56)

0.85 (0.46–1.56)

Non-Hodgkin lymphoma

206

16

1.28 (0.77–2.14)

1.45 (0.85–2.45)

Ovarian Cancer

157

11

1.15 (0.62–2.13)

1.18 (0.63–2.23)

Other internal malignanciesc

720

47

1.10 (0.81–1.48)

1.19 (0.88–1.62)

Skin cancers d

1 344 071 person-years

60 007 person-years

  

Melanoma

344

16

1.04 (0.63–1.72)

0.96 (0.57–1.62)

Squamous cell carcinoma

418

34

1.32 (0.93–1.88)

1.30 (0.90–1.88)

Basal cell carcinoma

4552

424

1.57 (1.42–1.73)e

1.50 (1.35–1.67)e

  1. aAdjusted for age, body mass index (BMI), alcohol consumption, physical activity, physical examination, multivitamin use, smoking status, oral contraceptive use, menopausal status and postmenopausal hormone use, as well as history of severe teenage acne, use of medications including tetracycline, isotretinoin and antibiotics.
  2. bAdditionally adjusted for personal history of benign breast disease, family history of breast cancer, age at first birth and parity, age at menarche, height, and BMI at age 18 years.
  3. cOther individual cancers each with cases <100.
  4. dAdditionally adjusted for natural hair colour, childhood tendency to sunburn, number of sunburns at ages 15–20 years, family history of melanoma, self-reported mole count on lower legs, sun exposures at high school and at age 25–35 years, and UV index at birth, age 15, and age 30 years.
  5. eP<0.05.
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