Table 3 Patient data, status and treatment results from MRI scans and from histopathology

From: TNF-alpha and melphalan-based isolated limb perfusion: no evidence supporting the early destruction of tumour vasculature

    

MRI

Histopathology

Pat.-No.

Age

Clinical status

Resection

Pre- to post-ILP contrast medium enhancement (%)

Max. tumour diameter (mm) before TM-ILP

Tumour depth (mm)

Pre- to post-ILP MRI tumour-volume (%)

Grade of regression (Salzer–Kuntschik)

Histopathologic regression (%)

Entity

1

46

No local recurrence

Resection

25

115

9

55

1

100

Undifferentiated pleomorphic sarcoma

2

61

Late progressive disease

No resection

50

53

17

61

  

Fibrosarcoma

3

75

No local recurrence

Resection

100

119

8

60

5

5

Dedifferentiated liposarcoma

4

76

Systemic progression of disease

No resection

25

66

2

63

  

Synovial sarcoma

5

44

No local recurrence

Resection

90

111

10

93

4

80

Myxoid round cell liposarcoma

6

59

No local recurrence

Resection

100

42

2

102

3

93

Undifferentiated pleomorphic sarcoma of the inflammatory type

7

68

Late local recurrence

No resection

50

19

6

22

  

Fibroblastic sarcoma

8

82

Tumour-related death

No resection

25

37

1

43

  

Undifferentiated pleomorphic sarcoma (spindle cell)

9

44

Lost to follow-up

Lost to follow-up

7

   

Undifferentiated pleomorphic sarcoma

10

52

Local recurrence

Resection

50

68

3

103

3

93

Squamous cell carcinoma

11

80

Ongoing complete remission

No resection

90

25

3

36

  

Malignant melanoma

Mean

   

61

66

6

64

 

74

 

Median

   

50

60

6

61

 

93

 

Minimum

   

25

19

1

22

 

5

 

Maximum

   

100

119

17

103

 

100

 

SD

   

31.6

37.6

4.8

27.7

 

39.4

 
  1. Abbreviations: SD= standard deviation; TM-ILP=Isolated limb perfusion with TNF-alpha and melphalan; TNF=tumour necrosis factor.