Table 3 Effect of pre-existing diabetes on total and breast cancer specific mortality in women with breast cancer

From: Pre-existing diabetes and breast cancer prognosis among elderly women

  

Hazard ratio (95% CI)

 

Cases (death)

Model—without adjustment

Model—only adjusting for age

Model 1 a

Model 2 b

Model 3 c

Total mortality

Diabetes (no)

2534 (587)

Reference

Reference

Reference

Reference

Reference

Diabetes (yes)

299 (94)

1.88 (1.51–2.34)

1.90 (1.53–2.36)

1.57 (1.23–2.01)

1.47 (1.15–1.89)

1.46 (1.12–1.86)

Breast cancer specific mortality using traditional method

Diabetes (no)

2534 (167)

Reference

Reference

Reference

Reference

Reference

Diabetes (yes)

299 (27)

1.70 (1.13–2.56)

1.73 (1.15–2.60)

1.47 (0.93–2.31)

1.18 (0.73–1.92)

1.39 (0.84–2.29)

Breast cancer specific mortality using competing risk model

Diabetes (no)

2534 (167)

Reference

Reference

Reference

Reference

Reference

Diabetes (yes)

299 (27)

1.58 (1.05–2.37)

1.60 (1.07–2.41)

1.36 (0.86–2.15)

1.13 (0.70–1.84)

1.32 (0.80–2.17)

  1. Abbreviation: CI=confidence interval
  2. aModel 1 adjusted for age at diagnosis, race/ethnicity, BMI, physical activity, alcohol intake, family history of cancer among females, comorbidity (0, 1, 2, 3 or more), total energy, percent calories from fat.
  3. bModel 2 further adjusted for factors that may be related to delayed detection (screening and stage).
  4. cModel 3 further adjusted for cancer treatment, including surgery, radiation and chemotherapy, and tumour markers (ER, PR and HER).
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