Table 4 Predictors of total diagnostic interval stratified by lung cancer and no cancer groups
Total cohort ( n =693) | Primary lung cancer (LC) ( n =153) | No cancer (NC) ( n =753) | ||||
|---|---|---|---|---|---|---|
Variable | Adjusted HR (95% CI) | P -value | Adjusted HR (95% CI) | P -value | Adjusted HR (95% CI) | P -value |
Age (years) | 1.00 (0.99–1.01) | 0.79 | 1.00 (0.97–1.02) | 0.75 | 1.00 (0.99–1.01) | 0.81 |
Gender (reference: female) | 0.91 (0.79–1.05) | 0.21 | 1.06 (0.69–1.63) | 0.79 | 0.90 (0.77–1.05) | 0.19 |
Educational status (reference: degree or higher) | ||||||
A level/GCSE/O level | 0.85 (0.71–1.01) | 0.06 | 0.72 (0.44–1.19) | 0.20 | 0.91 (0.75–1.11) | 0.36 |
Other/none | 0.88 (0.73–1.06) | 0.17 | 0.66 (0.42–1.05) | 0.08 | 0.93 (0.75–1.16) | 0.54 |
Smoking status (reference: smoker) | ||||||
Ex-smoker | 0.92 (0.73–1.16) | 0.50 | 1.29 (0.79–2.10) | 0.32 | 0.88 (0.67–1.17) | 0.40 |
Never smoker | 0.83 (0.65–1.06) | 0.14 | 1.27 (0.53–3.00) | 0.59 | 0.86 (0.64–1.15) | 0.31 |
Missing | 0.30 (0.04–2.21) | 0.24 | — | 0.32 (0.04–2.38) | 0.26 | |
Deprivation IMD (reference=1st quintile ‘least deprived’) | ||||||
2nd Quintile | 1.19 (0.98–1.43) | 0.08 | 0.98 (0.58–1.65) | 0.94 | 1.18 (0.95–1.47) | 0.14 |
3rd Quintile | 0.98 (0.80–1.20) | 0.84 | 1.34 (0.77–2.34) | 0.30 | 0.91 (0.72–1.15) | 0.44 |
4th Quintile | 1.03 (0.82–1.30) | 0.80 | 1.43 (0.78–2.63) | 0.25 | 0.97 (0.74–1.26) | 0.80 |
5th Quintile | 0.96 (0.77–1.20) | 0.71 | 0.87 (0.47–1.64) | 0.68 | 0.95 (0.74–1.23) | 0.71 |
Comorbidity | ||||||
Respiratory | 0.85 (0.72–0.99) | 0.04 | 0.78 (0.49–1.25) | 0.31 | 0.85 (0.71–1.02) | 0.07 |
Perceived family history cancer risk | 0.95 (0.82–1.11) | 0.55 | 0.76 (0.50–1.18) | 0.22 | 0.94 (0.79–1.12) | 0.50 |
First symptom/s | ||||||
Coughing up blood | 2.17 (1.63–2.89) | 0.00 | Not includeda | 2.41 (1.74–3.35) | 0.00 | |
Cough or worsening cough >3 weeks | 1.35 (1.17–1.56) | 0.00 | 1.16 (0.78–1.74) | 0.46 | 1.42 (1.20–1.67) | 0.00 |
Breathlessness or worsening >3 weeks | 0.96 (0.83–1.12) | 0.62 | 0.70 (0.45–1.08) | 0.10 | 1.00 (0.84–1.18) | 0.97 |
Chest/shoulder pain >3 weeks | 1.16 (0.96–1.41) | 0.12 | 1.79 (1.08–2.99) | 0.03 | 1.05 (0.85–1.31) | 0.63 |
Hoarseness >3 weeks | 1.20 (0.95–1.52) | 0.12 | 0.98 (0.48–2.01) | 0.97 | 1.24 (0.96–1.61) | 0.10 |
Decreased appetite | 1.54 (1.22–1.95) | 0.00 | 1.41 (0.78–2.53) | 0.25 | 1.54 (1.16–2.05) | 0.00 |
Unexplained weight loss | 0.79 (0.58–1.08) | 0.14 | 0.86 (0.43–1.71) | 0.66 | 0.69 (0.47–1.02) | 0.06 |
Fatigue or tiredness ‘unusual for you’ | 1.17 (0.99–1.39) | 0.06 | 1.16 (0.75–1.79) | 0.49 | 1.18 (0.96–1.43) | 0.11 |
Different ‘in yourself’ | 1.18 (0.99–1.41) | 0.06 | 1.52 (0.93–2.46) | 0.09 | 1.19 (0.97–1.45) | 0.10 |
