Table 5 Predictors of total diagnostic interval stratified by lung cancer stage
Early stage ( n =48) | Late stage ( n =103) | |||
|---|---|---|---|---|
Variable | Adjusted HR (95% CI) | P -value | Adjusted HR (95% CI) | P -value |
Age | 0.98 (0.93–1.03) | 0.39 | 1.01 (0.98–1.04) | 0.53 |
Gender (reference: female) | 2.87 (1.01–8.16) | 0.05 | 0.90 (0.51–1.56) | 0.70 |
Educational status (reference: degree or higher) | ||||
A level/GCSE/O level | 0.40 (0.13–1.23) | 0.11 | 0.76 (0.41–1.41) | 0.39 |
Other/none | 0.44 (0.16–1.17) | 0.10 | 0.63 (0.36–1.12) | 0.12 |
Smoking status (reference: smoker) | ||||
Ex-smoker | 1.52 (0.42–5.48) | 0.52 | 1.04 (0.58–1.88) | 0.89 |
Never smoker | 1.32 (0.33–5.24) | 0.70 | 1.02 (0.25–4.13) | 0.98 |
Deprivation IMD (reference=1st quintile ‘least deprived’) | ||||
2nd Quintile | 0.87 (0.30–2.50) | 0.79 | 1.21 (0.62–2.40) | 0.57 |
3rd Quintile | 2.33 (0.61–8.92) | 0.22 | 1.15 (0.59–2.25) | 0.68 |
4th Quintile | 1.36 (0.33–5.63) | 0.67 | 1.29 (0.62–2.66) | 0.50 |
5th Quintile | 2.70 (0.55–13.28) | 0.22 | 0.75 (0.36–1.56) | 0.44 |
Comorbidity | ||||
Respiratory | 0.97 (0.40–2.396) | 0.95 | 0.63 (0.34–1.18) | 0.15 |
Perceived family history cancer risk | 0.18 (0.06–0.51) | 0.00 | 1.17 (0.67–2.03) | 0.58 |
First symptom/s | ||||
Coughing up blood | Not includeda | — | Not includeda | — |
Cough or worsening cough >3 weeks | 0.58 (0.21–1.57) | 0.28 | 1.07 (0.66–1.72) | 0.79 |
Breathlessness or worsening >3 weeks | 0.24 (0.08–0.74) | 0.01 | 0.96 (0.55–1.70) | 0.90 |
Chest/shoulder pain >3 weeks | Not includeda | — | 1.66 (0.90–3.08) | 0.11 |
Hoarseness >3 weeks | Not includeda | — | Not includeda | — |
Decreased appetite | Not includeda | — | 1.29 (0.68–2.41) | 0.43 |
Unexplained weight loss | Not includeda | — | Not includeda | — |
Fatigue or tiredness ‘unusual for you’ | 0.40 (0.13–1.20) | 0.10 | 1.26 (0.72–2.20) | 0.42 |
Different ‘in yourself’ | 2.53 (0.81–7.90) | 0.11 | 1.59 (0.84–3.01) | 0.15 |
