Table 3 Downregulated genes in miR-221/222 transfectants and upregulated genes in the GEO database
Entrez gene ID | Symbol | Gene name | Location | PC3 miR-221 transfectant | PC3 miR-222 transfectant | DU145 miR-221 transfectant | DU145 miR-222 transfectant | Average | GEO fold change | No. of conserved sites | No. of poorly conserved sites |
|---|---|---|---|---|---|---|---|---|---|---|---|
23392 | KIAA0368 | Ecm29 (KIAA0368) | 9q31.3 | −1.28 | −1.05 | −0.82 | −0.62 | −0.94 | 0.999 | 1 | 0 |
159195 | USP54 | Ubiquitin-specific peptidase 54 | 10q22.2 | −0.73 | −0.65 | −0.19 | −0.15 | −0.43 | 0.869 | 0 | 1 |
51809 | GALNT7 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) | 4q34.1 | −0.75 | −0.67 | −0.85 | −0.94 | −0.80 | 0.833 | 0 | 1 |
10238 | DCAF7 | DDB1- and CUL4-associated factor 7 | 17q23.3 | −0.78 | −0.87 | −0.58 | −0.47 | −0.67 | 0.767 | 1 | 1 |
55920 | RCC2 | Regulator of chromosome condensation 2 | 1p36.13 | −0.48 | −0.53 | −0.12 | −0.18 | −0.33 | 0.734 | 0 | 1 |
23097 | CDK19 | Cyclin-dependent kinase 19 | 6q21 | −2.77 | −2.18 | −0.56 | −0.18 | −1.42 | 0.732 | 1 | 2 |
58508 | MLL3 | Myeloid/lymphoid or mixed-lineage leukaemia 3 | 7q36.1 | −1.44 | −1.40 | −0.42 | −0.28 | −0.88 | 0.697 | 0 | 1 |
9870 | KIAA0317 | KIAA0317 | 14q24.3 | −0.67 | −0.47 | −0.36 | −0.41 | −0.48 | 0.621 | 0 | 1 |
54874 | FNBP1L | Formin-binding protein 1-like | 1p22.1 | −1.20 | −1.25 | −0.22 | −0.21 | −0.72 | 0.613 | 0 | 1 |
55884 | WSB2 | WD repeat and SOCS box containing 2 | 12q24.23 | −2.64 | −2.71 | −1.58 | −1.21 | −2.03 | 0.569 | 1 | 1 |
6319 | SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 10q24.31 | −1.78 | −1.81 | −0.49 | −0.15 | −1.06 | 0.545 | 0 | 1 |
2017 | CTTN | Cortactin | 11q13.3 | −1.12 | −1.01 | −0.32 | −0.14 | −0.65 | 0.542 | 0 | 1 |
5451 | POU2F1 | POU class 2 homeobox 1 | 1q24.2 | −0.46 | −0.43 | −0.21 | −0.26 | −0.34 | 0.524 | 0 | 1 |
204851 | HIPK1 | Homeodomain interacting protein kinase 1 | 1p13.2 | −2.00 | −1.70 | −0.81 | −0.56 | −1.27 | 0.519 | 1 | 0 |
9265 | CYTH3 | Cytohesin 3 | 7p22.1 | −0.53 | −0.43 | −0.58 | −0.39 | −0.48 | 0.518 | 0 | 1 |
23126 | POGZ | Pogo transposable element with ZNF domain | 1q21.3 | −0.64 | −0.80 | −0.26 | −0.16 | −0.46 | 0.515 | 1 | 0 |
2799 | GNS | Glucosamine (N-acetyl)-6-sulfatase | 12q14.3 | −0.65 | −1.16 | −0.16 | −0.29 | −0.57 | 0.513 | 0 | 1 |
