Table 2 Clinical assumptions used for population-screening example
From: Polygenic susceptibility to testicular cancer: implications for personalised health care
Assumption | Value (%) | Reference |
|---|---|---|
Lifetime risk of TGCT | 0.5 | |
TGCT mortality rate | 2.8 | September 2014 |
Frequency of surgical complications from testicular biopsy | 2.8 | |
Semen assay – sensitivity | 67.0 | |
Semen assay – specificity | 98.0 | |
Overall rate of chemotherapy administration in TGCT | 65.0 | Estimate from Royal Marsden Hospital patient data |
Genotyping uptake in population | 100.0 | Theoretical estimate |
Sensitivity of testicular biopsy to detect CIS | 97.5 | |
Remaining risk of progression to invasive TGCT, following CIS detection and preventative orchidectomy | 0.0 | Theoretical assumption |
