Table 3 Impact of individual comorbidities on stage of disease at diagnosis (adjusted odds ratios (ORs) from multinomial logistic regression models), for the total cohort
From: The impact of patient comorbidity on cancer stage at diagnosis
Odds ratio for stage at diagnosis (OR, 95% CI) | ||||
|---|---|---|---|---|
Comorbid condition | Local | Regional | Distant | Unknown |
Total cohort a | ||||
Alcohol abuse (‘Yes’ vs ‘No’) | Ref | 1.91 (1.06–3.46) | 2.4 (1.25–4.61) | 3.6 (1.98–6.55) |
Anaemia | Ref | 1 (0.8–1.23) | 0.94 (0.72–1.22) | 1.03 (0.81–1.32) |
Angina | Ref | 1.01 (0.8–1.27) | 0.9 (0.67–1.21) | 1.16 (0.9–1.5) |
Anxiety and behavioural disorders | Ref | 0.97 (0.61–1.54) | 1.45 (0.83–2.51) | 1.58 (0.96–2.58) |
Cardiac arrhythmia | Ref | 0.95 (0.79–1.15) | 1.17 (0.94–1.46) | 1.58 (1.3–1.91) |
Cardiac valve disorder | Ref | 0.78 (0.57–1.08) | 1.02 (0.7–1.49) | 1.43 (1.04–1.96) |
Cerebrovascular disease | Ref | 1.02 (0.79–1.31) | 1.56 (1.18–2.07) | 1.55 (1.2–2.01) |
Congestive heart failure | Ref | 1.11 (0.85–1.45) | 1.54 (1.14–2.07) | 2.83 (2.21–3.63) |
Coagulopathy/blood disorders | Ref | 1.13 (0.94–1.35) | 1.29 (1.05–1.59) | 1.33 (1.09–1.62) |
Connective tissue disease | Ref | 0.78 (0.46–1.33) | 0.87 (0.45–1.67) | 1.85 (1.13–3.03) |
COPD | Ref | 0.87 (0.69–1.08) | 1.29 (1–1.66) | 1.74 (1.4–2.16) |
Dementia | Ref | 2.33 (1.22–4.46) | 6.25 (3.27–11.96) | 8.72 (4.81–15.81) |
Diabetes no complications | Ref | 0.9 (0.74–1.1) | 1.07 (0.84–1.35) | 0.87 (0.69–1.1) |
Diabetes with complications | Ref | 1.24 (1–1.55) | 1.18 (0.91–1.53) | 1.31 (1.03–1.66) |
Endocrine disorders | Ref | 1.59 (1.07–2.35) | 1.61 (1–2.57) | 1.49 (0.95–2.33) |
Epilepsy | Ref | 0.95 (0.45–1.99) | 1.99 (0.9–4.37) | 1.38 (0.6–3.15) |
Eye problems | Ref | 1.24 (0.93–1.67) | 1.23 (0.85–1.76) | 1.39 (1.01–1.91) |
GI disease | Ref | 0.97 (0.7–1.36) | 1.44 (1.02–2.03) | 1.19 (0.85–1.65) |
Hepatitis: chronic viral | Ref | 0.23 (0.11–0.45) | 0.42 (0.24–0.73) | 1.47 (0.94–2.29) |
Hypertension | Ref | 0.93 (0.81–1.07) | 1.08 (0.92–1.27) | 1.34 (1.16–1.55) |
Inflammatory bowel disorder | Ref | 1.24 (0.99–1.56) | 1.4 (1.06–1.84) | 1.42 (1.1–1.85) |
Inner ear disorder | Ref | 0.89 (0.61–1.31) | 0.97 (0.61–1.54) | 1.3 (0.89–1.91) |
Intestinal disorders | Ref | 0.78 (0.65–0.94) | 0.55 (0.43–0.72) | 0.59 (0.47–0.75) |
Joint or spinal disorders | Ref | 0.97 (0.65–1.45) | 1.74 (1.13–2.68) | 1.65 (1.1–2.46) |
Liver—moderate/severe disease | Ref | 0.73 (0.48–1.12) | 1.21 (0.8–1.82) | 2.06 (1.42–2.99) |
Major psychiatric condition | Ref | 1.14 (0.76–1.71) | 1.72 (1.07–2.76) | 1.67 (1.06–2.61) |
Malnutrition | Ref | 1.45 (0.79–2.65) | 1.95 (0.99–3.84) | 2.6 (1.42–4.74) |
Metabolic disorder | Ref | 1.11 (0.93–1.32) | 1.27 (1.04–1.56) | 1.07 (0.88–1.31) |
Myocardial infarction | Ref | 1.07 (0.84–1.37) | 1.22 (0.92–1.62) | 1.78 (1.4–2.26) |
Neurological conditions excl. epilepsy | Ref | 1.86 (1.19–2.89) | 2.26 (1.36–3.75) | 3.54 (2.28–5.49) |
Obesity | Ref | 1.12 (0.85–1.46) | 0.74 (0.52–1.05) | 1.09 (0.79–1.51) |
Osteoporosis and bone disorders | Ref | 0.85 (0.49–1.47) | 1.71 (0.96–3.03) | 2.84 (1.78–4.56) |
Other cardiac conditions | Ref | 0.97 (0.8–1.19) | 0.94 (0.73–1.21) | 1.28 (1.04–1.58) |
Other malignancy | Ref | 0.97 (0.77–1.23) | 1.24 (0.96–1.62) | 1.2 (0.93–1.55) |
Paralysis | Ref | 0.9 (0.63–1.3) | 1.62 (1.1–2.39) | 1.54 (1.08–2.19) |
Peripheral nerve or muscular disorder | Ref | 1.42 (0.78–2.57) | 1.61 (0.81–3.21) | 1.68 (0.89–3.19) |
Pulmonary circulation disorder | Ref | 1.09 (0.59–2.01) | 2.41 (1.29–4.48) | 2.42 (1.33–4.39) |
Peripheral vascular disease | Ref | 1.12 (0.81–1.54) | 1.43 (0.99–2.06) | 1.41 (1.02–1.96) |
Renal disease | Ref | 1.04 (0.8–1.35) | 1.3 (0.97–1.75) | 1.68 (1.3–2.17) |
Sleep disorder | Ref | 1 (0.55–1.83) | 0.79 (0.38–1.67) | 0.72 (0.34–1.53) |
Urinary tract disorder | Ref | 1.35 (0.86–2.11) | 1.56 (0.95–2.55) | 2.44 (1.61–3.7) |
Venous insufficiency | Ref | — | — | 4.07 (1.62–10.22) |
