Table 2 Baseline patient clinical characteristics

From: Complications of hyperglycaemia with PI3K–AKT–mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials

 

Cases

Controls

N

387

109

Sex

Female

193 (49.9%)

53 (48.6%)

Male

194 (50.1%)

56 (51.4%)

Age, year median (range)

59.7 (22.25–81.08)

56.3 (17.49–88.3)

BMI, kg m−2 median (range)

25.93 (15–43)

27.33 (15–40)

Performance status

0

106 (27.4%)

25 (22.9%)

1

277 (71.6%)

82 (75.3%)

2

4 (1.0%)

2 (1.8%)

Number of previous lines of chemotherapy

2 (0–11)

2 (0–11)

Tumour type

Lung and mesothelioma

48 (12.4%)

11 (10.1%)

Colorectal

99 (25.6%)

16 (14.7%)

Gynaecological (ovarian, cervical, endometrial)

59 (15.2%)

6 (5.5%)

Breast

33 (8.5%)

15 (13.8%)

Prostate

22 (5.7%)

10 (9.2%)

RCC

17 (4.4%)

3 (2.8%)

Others

109 (28.2%)

48 (44.0%)

RMH score a

0

85 (22.0%)

25 (22.9%)

1

129 (33.3%)

32 (29.4%)

2

107 (27.6%)

32 (29.4%)

3

52 (13.5%)

20 (18.3%)

Unknown

14 (3.6%)

Time on trial (days)

94.61 (1–1524)

124,75 (1–1096)

  1. Abbreviations: BMI=body mass index; RMH=The Royal Marsden Hospital.
  2. Baseline characteristics such as age at the time of recruitment, tumour type, number of previous lines of chemotherapy and performance status were balanced between cases and controls.
  3. aRMH score: albumin+number metastatic sites+LDH.