Table 2 Uni- and multivariate analyses for OS
From: Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer
TS ( N =596) | VS ( N =508) | |||||||
|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Gender | ||||||||
F vs M | 1.14 (0.92–1.42) | 0.222 | – | – | 1.17 (0.95–1.46) | 0.15 | – | – |
Age (cut-off: 65 years) | ||||||||
⩾65 vs <65 | 1.67 (1.35–2.07) | 0.0001 | 1.86 (1.38–2.49) | <0.0001 | 1.21 (0.98–1.49) | 0.08 | – | – |
ECOG-PS | ||||||||
⩾2 vs <2 | 2.12 (1.70–2.63) | 0.0001 | 1.54 (1.14–2.07) | 0.004 | 1.11 (0.83–1.47) | 0.49 | – | – |
Synchronous metastases | ||||||||
yes vs no | 1.31 (1.03–1.66) | 0.026 | – | – | 1.05 (0.85–1.30) | 0.66 | – | – |
Primary site | ||||||||
right vs left | 1.52 (1.22–1.88) | 0.0001 | – | – | 1.48 (1.18–1.86) | 0.001 | 1.33 (1.05–1.69) | 0.02 |
Primary resected | ||||||||
no vs yes | 1.97 (1.53–2.53) | 0.0001 | 2.27 (1.52–3.39) | <0.0001 | 1.11 (0.95–1.38) | 0.23 | – | – |
Mucinous histology | ||||||||
yes vs no | 1.38 (1.05–1.82) | 0.018 | 1.43 (0.97–2.08) | 0.065 | 1.26 (0.97–1.63) | 0.09 | – | – |
Number of metastatic sites | ||||||||
>1 vs 1 | 2.08 (1.67–2.59) | 0.0001 | 1.83 (1.38–2.43) | <0.0001 | 1.94 (1.56–2.42) | <0.0001 | 1.76 (1.38–2.25) | <0.0001 |
Peritoneal metastases | ||||||||
yes vs no | 1.69 (1.31–2.18) | 0.0001 | – | – | 1.37 (1.06–1.76) | 0.01 | – | – |
Lung metastases | ||||||||
yes vs no | 1.05 (0.82–1.35) | 0.646 | – | – | 0.99 (0.74–1.21) | 0.53 | – | – |
Distant lymph-node metastases | ||||||||
yes vs no | 1.54 (1.18–2.02) | 0.002 | – | – | 1.92 (1.50–2.47) | <0.0001 | 1.31 (0.99–1.74) | 0.06 |
Tumour grading | ||||||||
3–4 vs 1–2 | 2.34 (1.83–3.01) | 0.0001 | – | – | 1.23 (0.98–1.56) | 0.08 | – | – |
RAS | ||||||||
mut vs wt | 1.20 (0.97–1.49) | 0.088 | – | – | 1.01 (0.82–1.25) | 0.91 | – | – |
BRAF | ||||||||
mut vs wt | 2.56 (1.84–3.56) | 0.0001 | 2.98 (1.96–4.52) | <0.0001 | 2.72 (1.92–3.85) | <0.0001 | 2.33 (1.61–3.35) | <0.0001 |
