Table 3 Final parsimonious multivariable models for recurrence-free, cancer-specific, and overall survival

From: Identification of the best complete blood count-based predictors for bladder cancer outcomes in patients undergoing radical cystectomy

Parameter

HR (95% CI)

P- value

Model for recurrence-free survival a

T-stage, pT3-4 vs pT0-2

1.58 (1.03–2.42)

0.03

N-stage, N+ vs N0

2.15 (2.82–2.53)

<0.0001

Lymphovascular invasion

1.72 (1.04–2.86)

0.03

Positive surgical margin

2.16 (1.42–3.28)

<0.001

Neutrophil–lymphocyte ratio, per 1-unit increaseb

1.52 (1.17–1.98)

0.002

Model for cancer-specific survival c

T-stage, pT3-4 vs pT0-2

1.67 (1.07–2.62)

0.02

N-stage, N+ vs N0

2.13 (1.27–3.57)

0.004

Lymphovascular invasion

1.75 (0.94–3.28)

0.08

Positive surgical margin

1.82 (0.88–3.79)

0.11

Haemoglobin (per 1 g/l increase)

0.91 (0.86–0.95)

<0.001

Neutrophil–lymphocyte ratio, per 1-unit increaseb

1.47 (1.20–1.80)

<0.001

Model for overall survival d

Age, per 1 year increase

1.03 (1.01–1.04)

0.008

Charlson co-morbidity index, per 1-point increase

1.16 (1.03–1.32)

0.01

T-stage, pT3-4 vs pT0-2

1.42 (0.83–2.45)

0.20

N-stage, N+ vs N0

1.55 (1.12–2.14)

0.008

Lymphovascular invasion

1.74 (1.03–2.93)

0.04

Positive surgical margin

1.86 (0.90–3.82)

0.09

Haemoglobin, per 1 g/dl increase

0.90 (0.88–0.93)

<0.001

Neutrophil–lymphocyte ratio, per 1-unit increaseb

1.56 (1.16–2.10)

0.004

  1. Abbreviations: AIC=Akaike Information Criterion; CI=confidence interval; HR=hazard ratio.
  2. aLikelihood ratio omnibus test: χ2=84.8, dF=5, P<0.001; AIC=1407.0.
  3. bVariable was log-transformed, and therefore hazard ratios represent effect per 1 log-unit.
  4. cLikelihood ratio omnibus test: χ2=68.9, dF=6, P<0.001; AIC=1101.6.
  5. dLikelihood ratio omnibus test: χ2=111.0, dF=8, P<0.001; AIC=1780.7.
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