Table 1 Univariate and multivariate analysis for overall survival (covariates included in multivariate model highlighted in bold)

From: Systemic neutrophil-to-lymphocyte ratio in colorectal cancer: the relationship to patient survival, tumour biology and local lymphocytic response to tumour

  

Univariate

Multivariate

Covariate

N

P -value

HR

95% CI

P -value

HR

95% CI

NLR

<5

270

—

1.00

—

—

1.00

—

⩾5

88

<0.001

2.616

1.925–3.553

<0.001

1.819

1.310–2.526

Age (years)

⩽70

129

—

1.00

—

—

1.00

—

>70

229

<0.001

2.549

1.799–3.612

<0.001

2.964

2.045–4.297

Gender

M

202

—

1.00

—

—

—

—

F

156

0.920

1.015

0.758–1.360

—

—

—

CRP (U)

⩽10

74

—

1.00

—

—

—

—

>10

90

0.025

1.640

1.063–2.528

—

—

—

Total lymph nodes found

0–15

178

—

1.00

—

—

—

—

>15

178

0.020

1.419

1.057–1.904

—

—

—

EMVI

Y

138

—

1.00

—

—

1.00

—

N

213

<0.001

2.210

1.641–2.976

0.139

1.294

0.920–1.820

pT-stage

1

11

—

1.00

—

—

—

—

2

32

0.596

0.731

0.229–2.330

—

—

—

3

212

0.757

1.171

0.430–3.188

—

—

—

4

98

0.036

2.931

1.070–8.024

—

—

—

pN-sta ge

0

203

—

1.00

—

—

—

—

1

88

0.048

1.454

1.002–2.108

—

—

—

2

65

<0.001

3.712

2.615–5.272

—

—

—

Complete resection

Y

310

—

1.00

—

—

—

—

N

37

0.130

1.435

0.917–2.246

—

—

—

Site of tumour

Colon

261

—

1.00

—

—

—

—

Rectum

97

0.161

0.783

0.556–1.102

—

—

—

Dukes’ stage

A

38

—

1.00

—

—

1.00

—

B

163

0.510

1.223

0.672–2.228

0.999

0.999

5.33–1.875

C

119

0.02

2.701

1.430–5.100

0.025

2.097

1.098–4.007

D

37

<0.001

6.776

3.408–13.474

<0.001

6.665

3.241–13.707

  1. Abbreviations: CI=confidence interval; CRP=c-reactive protein; EMVI=extramural vascular invasion; F=female; HR=hazard ratio; M=male; N=no; NLR=neutrophil-to-lymphocyte ratio; Y=yes.
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