Table 1 Parameters for sensitivity analyses
From: Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening
Parameter | Mean | Plausible range | Distribution | Source |
|---|---|---|---|---|
Costs (2012 US$) | ||||
Colposcopy | $292 | $206–$371 | Log-normal | (8) |
Biopsy | $322 | $227–$408 | Log-normal | |
DNA ploidy analysis | $44 | $44–$88 | n/a | Assumption (see text) |
Papanicolaou smear | $88 | $44–$252 | Gamma | (26) |
Treating HSIL | $4996 | $2268–$6887 | Log-normal | (8) |
Treating cancer stage I | $28 914 | $15 467–$35 962 | Log-normal | |
Treating cancer stage II | $44 357 | $19 228–$47 667 | Log-normal | |
Treating cancer stage III | $44 357 | $19 228–$47 667 | Log-normal | |
Treating cancer stage IV | $66 006 | $20 762–$76 213 | Log-normal | |
Screening test operating characteristics | ||||
Sensitivity, Papanicolaou smear | 0.84 | 0.69–0.88 | Beta | (26) |
Specificity, Papanicolaou smear | 0.88 | 0.77–0.93 | Beta | |
Sensitivity, ploidy 1 cell | 0.74 | 0.67–0.79 | Beta | (1) |
Specificity, ploidy 1 cell | 0.82 | 0.79–0.83 | Beta | |
Sensitivity, ploidy 2 cell | 0.65 | 0.58–0.71 | Beta | |
Specificity, ploidy 2 cell | 0.90 | 0.88–0.92 | Beta | |
Sensitivity, ploidy 3 cell | 0.59 | 0.52–0.65 | Beta | |
Specificity, ploidy 3 cell | 0.93 | 0.92–0.94 | Beta | |
Sensitivity, ploidy 4 cell | 0.55 | 0.48–0.61 | Beta | |
Specificity, ploidy 4 cell | 0.95 | 0.93–0.96 | Beta | |
Sensitivity, ploidy 5 cell | 0.51 | 0.43–0.56 | Beta | |
Specificity, ploidy 5 cell | 0.95 | 0.93–0.96 | Beta | |
