Table 3 The most cost-effective strategy, its next best alternative, and the Papanicolaou smear with the ICERs in a two-way sensitivity analysis with respect to screening frequency and ploidy cost factor

From: Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening

 

Ploidy cost factor=0.5

Ploidy cost factor=0.75

Ploidy cost factor=1.0

Screening frequency

Screening strategy

Strategy, ICER

Screening strategy

Strategy, ICER

Screening strategy

Strategy, ICER

Screening every 1 year

Most cost-effective

Ploidy 4 cell, $42 655

Most cost-effective

Ploidy 4 cell, $54 008

Most cost-effective

Ploidy 4 cell, $65 361

 

Next best alternativea

Ploidy 3 cell, more than 1Mb

Next best alternative

Ploidy 3 cell, more than 1M

Next best alternative

Ploidy 3 cell, more than 1M

 

Papanicolaou smear

Dominated

Papanicolaou smear

Dominated

Papanicolaou smear

Dominated

Screening every 2 years

Most cost-effective

Ploidy 4 cell, $24 161

Most cost-effective

Ploidy 4 cell, $30 699

Most cost-effective

Ploidy 4 cell, $37 238

 

Next best alternative

Ploidy 3 cell, $284 249

Next best alternative

Ploidy 3 cell, $297 995

Next best alternative

Papanicolaou smear, $276 891

 

Papanicolaou smear

$463 506

Papanicolaou smear

$351 416

Papanicolaou smear

$276 891

Screening every 3 years

Most cost-effective

Ploidy 4 cell, $18 824

Most cost-effective

Ploidy 4 cell, $23 270

Most cost-effective

Ploidy 4 cell, $28 277

 

Next best alternative

Ploidy 3 cell, $132 803

Next best alternative

Ploidy 3 cell, $139 252

Next best alternative

Papanicolaou smear, $119 198

 

Papanicolaou smear

$192 502

Papanicolaou smear

$148 501

Papanicolaou smear

$119 198

Screening every 5 years

Most cost-effective

Ploidy 4 cell, $13 157

Most cost-effective

Ploidy 4 cell, $16 916

Most cost-effective

Ploidy 4 cell, $20 674

 

Next best alternative

Ploidy 3 cell, $66 184

Next best alternative

Ploidy 3 cell, $69 444

Next best alternative

Papanicolaou smear, $57 543

 

Papanicolaou smear

$92 403

Papanicolaou smear

$71 278

Papanicolaou smear

$57 543

Screening every 10 years

Most cost-effective

Papanicolaou smear, $47 176

Most cost-effective

Papanicolaou smear, $36 727

Most cost-effective

Papanicolaou smear, $29 655

 

Next best alternative

n/a

Next best alternative

n/a

Next best alternative

n/a

 

Papanicolaou smear

$47 176

Papanicolaou smear

$36 727

Papanicolaou smear

$29 655

  1. aCompared to the most cost-effective strategy.
  2. bMore than $1 000 000/QALY.