Figure 2 | British Journal of Cancer

Figure 2

From: Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation

Figure 2

Altered expression of poorly differentiated PDAC cell markers in GALNT3 knockdown cells. (A) Stable knockdown of GALNT3 was carried out using GALNT3-specific shRNA in four different PDAC cells—CD18/HPAF, BxPC3, Capan-1 and T3M4. Beta-actin was used as a loading control. (B) VVA lectin blot demonstrates decrease of Tn carbohydrate antigen in GALNT3 knockdown PDAC cells. (C and D) Immunoblot analysis shows altered expression of differentiation markers with increased expression of Sox2 and decreased expression of SLea in GALNT3 knockdown PDAC cells.

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