Figure 1

Immunohistochemistry for CD31 and Ki-67. (A–C) Examples of CRC ‘hotspots’ with high, medium and low MVD, respectively. Arrows highlight two of the vessels in each case. All images were captured at × 200 magnification. D–F, examples of CRCs with a high, medium and low PI respectively. All images were captured at × 400 magnification.