Table 1 Putative candidate of target genes

From: Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer

    

TargetScan

Gene expression omnibus (GSE11783+GSE31684)

Entrez gene ID

Gene symbol

Description

Genomic location

Number of conserved sites

Number of poorly conserved sites

Fold change

P -value

647309

GEMC1

Geminin coiled-coil domain-containing protein 1

3q28

2

0

10.139

9.420E−05

3759

KCNJ2

Potassium inwardly rectifying channel, subfamily J, member 2

17q24.3

2

0

6.435

5.670E−05

4017

LOXL2

Lysyl oxidase-like 2

8p21.3

2

0

4.706

5.316E−05

5352

PLOD2

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

3q24

2

0

4.616

1.135E−04

170692

ADAMTS18

ADAM metallopeptidase with thrombospondin type 1 motif, 18

16q23

2

0

4.186

4.376E−05

55117

SLC6A15

Solute carrier family 6 (neutral amino-acid transporter), member 15

12q21.3

2

0

4.119

1.640E−04

144455

E2F7

E2F transcription factor 7

12q21.2

2

0

3.726

5.316E−05

23657

SLC7A11

Solute carrier family 7 (anionic amino-acid transporter light chain, xc system), member 11

4q28.3

2

2

3.381

1.003E−04

84206

MEX3B

Mex-3 homologue B (Caenorhabditis elegans)

15q25.2

2

0

3.293

9.231E−03

1993

ELAVL2

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

9p21

3

0

3.237

7.790E−04

10847

SRCAP

Snf2-related CREBBP activator protein

16p11.2

2

0

2.818

8.308E−05

7468

WHSC1

Wolf–Hirschhorn syndrome candidate 1

4p16.3

2

0

2.590

4.670E−05

9120

SLC16A6

Solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

17q24.2

2

0

2.431

1.285E−04

54620

FBXL19

F-box and leucine-rich repeat protein 19

16p11.2

2

0

2.429

1.405E−03

10622

POLR3G

Polymerase (RNA) III (DNA directed) polypeptide G (32 kDa)

5q14.3

2

2

2.281

1.642E−03

64768

IPPK

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase

9q22.31

2

0

2.223

1.067E−04

23276

KLHL18

Kelch-like 18 (Drosophila)

3p21.31

2

1

1.854

4.670E−05

124801

LSM12

LSM12 homologue (Saccharomyces cerevisiae)

17q21.31

2

0

1.795

1.003E−04

54726

OTUD4

OTU domain containing 4

4q31.21

2

1

1.589

2.975E−04

2182

ACSL4

Acyl-CoA synthetase long-chain family member 4

Xq22.3-q23

2

0

1.589

8.447E−03

51701

NLK

Nemo-like kinase

17q11.2

2

1

1.548

1.405E−03

200424

TET3

Tet oncogene family member 3

2p13.1

3

1

1.456

1.421E−02

26973

CHORDC1

Cysteine and histidine-rich domain (CHORD) containing 1

11q14.3

2

1

1.435

7.383E−03

23633

KPNA6

Karyopherin α6 (importin α7)

1p35.1

2

1

1.413

7.373E−04

85403

EAF1

ELL-associated factor 1

3p25.1

2

1

1.372

1.148Ev02

27

ABL2

v-abl Abelson murine leukaemia viral oncogene homologue 2

1q25.2

3

2

1.371

3.487E−03

23367

LARP1

La ribonucleoprotein domain family, member 1

5q33.2

2

1

1.299

2.057E−02

114885

OSBPL11

Oxysterol binding protein-like 11

3q21

2

0

1.289

1.749E−02

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