Figure 1 | British Journal of Cancer

Figure 1

From: ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Figure 1

Cross-resistance of paclitaxel- and olaparib-resistant ovarian cancer cell lines. Novel ovarian cancer A2780-derived paclitaxel (A2780pacR) and olaparib (A2780olapR) resistant cell lines were created as described in Materials and Methods section. MTT chemosensitivity assays were used to compare cell viability following exposure to serial dilutions of (A and D) paclitaxel and (B and C) olaparib in A2780 and A2780pacR (A and C) and A2780olapR (B and D) cells. Chemosensitivity values obtained from triplicate replicate experiments, expressed as IC50 values, are summarised in panel E.

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