Table 2 OR and 95% CI from conditional logistic regression of overall prostate cancer comparision of the 90th and 10th percentiles for serum metabolites (P<0.05) sorted by chemical class, sub-pathway, and P-valuea,b

From: Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial

Metabolite

Sub-pathway

OR

95% CI

P -value

P -value for chemical class

Amino acids and amino acids derivatives

0.20

Pyroglutamine

Glutamate metabolism

0.53

0.36, 0.78

0.0013

 

Phenylpyruvate

Phenylalanine and tyrosine metabolism

0.46

0.28, 0.75

0.0022

 

N-Acetylcitrulline

Urea cycle; arginine and proline metabolism

0.58

0.41, 0.84

0.0034

 

Homocitrulline

Urea cycle; arginine and proline metabolism

0.69

0.47, 1.00

0.0480

 

N-Acetylarginine

Urea cycle; arginine and proline metabolism

0.69

0.48, 1.00

0.0490

 

N-Acetyltryptophan

Tryptophan metabolism

0.67

0.49, 0.92

0.0122

 

N-Acetylkynurenine

Tryptophan metabolism

0.62

0.40, 0.95

0.0267

 

Tryptophan

Tryptophan metabolism

0.72

0.51, 1.00

0.0490

 

5-Methylthioadenosine

Polyamine metabolism

0.64

0.45, 0.93

0.0193

 

Trans-urocanate

Histidine metabolism

1.50

1.01, 2.23

0.0467

 

Cofactors and vitamins

0.20

Gulonic acid

Ascorbate and aldarate metabolism

0.73

0.56, 0.96

0.0239

 

Energy

0.29

Citrate

TCA cycle

1.54

1.04, 2.28

0.0294

 

Lipids

0.43

Stearoylcarnitine

Fatty acid metabolism (acyl carnitine)

1.74

1.17, 2.59

0.0063

 

Palmitoylcarnitine

Fatty acid metabolism (acyl carnitine)

1.49

1.02, 2.16

0.0389

 

15-Methylpalmitate

Fatty acid, branched

1.63

1.12, 2.38

0.0112

 

17-Methylstearate

Fatty acid, branched

1.47

1.03, 2.11

0.0354

 

Hexadecanedioate

Fatty acid, dicarboxylate

1.45

1.07, 1.98

0.0167

 

Caproate (6:0)

Medium-chain fatty acid

1.44

1.05, 1.98

0.0248

 

1-Palmitoleoyl-2-linoleoyl-GPC (16:1/18:2)

Phospholipid metabolism

0.60

0.40, 0.88

0.0096

 

1-Palmitoyl-2-arachidonoyl-GPI (16:0/20:4)

Phospholipid metabolism

1.64

1.09, 2.47

0.0187

 

Trimethylamine-N-oxide

Phospholipid metabolism

0.68

0.47, 0.97

0.0327

 

1-Linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)

Phospholipid metabolism

1.48

1.01, 2.16

0.0425

 

Tauro-beta-muricholate

Primary bile acid metabolism

0.68

0.48, 0.97

0.0329

 

1-Arachidonoyl-GPC (20:4n6)

Lysolipid

1.46

1.01, 2.10

0.0457

 

Nucleotide

0.61

2′-Deoxyuridine

Pyrimidine metabolism

1.47

1.07, 2.03

0.0191

 

Peptides

0.092

Gamma-glutamylphenylalanine

Gamma-glutamyl amino acid

0.51

0.34, 0.78

0.0015

 

Leucylglutamine

Dipeptide

0.67

0.47, 0.97

0.0356

 
  1. Abbreviations: CI=confidence interval; GPC=glycerophosphocholine; GPI=glycerophosphoinositol; OR=odds ratio; TCA=tricarboxylic acid cycle.
  2. aThe odds ratio per 80th percentile increase in metabolite. On the basis of 380 case–control pairs.
  3. bAll metabolites had detectable values in >90% of the study population with the exception of tauro-beta-muricholate and leucylglutamine (41% and 61%, respectively).
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