Table 4 OR and 95% CI from conditional logistic regression of non-aggressive prostate cancer comparision of the 90th and 10th percentiles for serum metabolites (P<0.05) sorted by chemical class, sub-pathway, and P-valuea,b

From: Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial

Metabolite

Sub-pathway

OR

95% CI

P -value

P -value for chemical class

Amino acids and amino acids derivatives

0.69

2-Aminoadipate

Lysine metabolism

0.63

0.41, 0.96

0.0311

 

Pipecolate

Lysine metabolism

0.68

0.48, 0.97

0.0332

 

3-Indoxyl sulfate

Tryptophan metabolism

0.70

0.49, 1.00

0.0483

 

Cofactors and vitamins

0.18

Alpha-CEHC glucuronide

Tocopherol metabolism

0.63

0.44, 0.90

0.0105

 

Gamma-tocopherol/beta-tocopherol

Tocopherol metabolism

1.51

1.07, 2.14

0.0196

 

Alpha-CEHC sulfate

Tocopherol metabolism

0.68

0.49, 0.95

0.0242

 

Alpha-tocopherol

Tocopherol metabolism

0.66

0.45, 0.96

0.0278

 

Lipids

0.32

1-Palmitoleoyl-2-linoleoyl-GPC (16:1/18:2)

Phospholipid metabolism

0.58

0.40, 0.86

0.0060

 

1-Palmitoyl-2-linolenoyl-GPC (16:0/18:3)

Phospholipid metabolism

1.62

1.05, 2.49

0.0293

 

1-Linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)

Phospholipid metabolism

1.50

1.04, 2.16

0.0303

 

Taurocholate

Primary bile acid metabolism

0.60

0.40, 0.88

0.0094

 

Glycocholate

Primary bile acid metabolism

0.69

0.49, 0.96

0.0272

 

4-Androsten-3beta,17beta-diol monosulfate

Steroid

0.62

0.43, 0.90

0.0117

 

5Alpha-androstan-3alpha,17beta-diol monosulfate

Steroid

0.61

0.40, 0.92

0.0187

 

Dehydroepiandrosterone sulfate

Steroid

0.64

0.44, 0.93

0.0204

 

17Alpha-hydroxypregnenolone sulfate

Steroid

0.70

0.51, 0.97

0.0303

 

4-Androsten-3beta,17beta-diol disulfate

Steroid

0.72

0.52, 0.99

0.0431

 

4-Androsten-3alpha,17alpha-diol monosulfate

Steroid

0.68

0.47, 0.99

0.0445

 

1-(1-Enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)

Plasmalogen

1.49

1.06, 2.10

0.0229

 

2-Hydroxyadipate

Fatty acid, dicarboxylate

0.66

0.45, 0.96

0.028

 

2-Stearoyl-GPE (18:0)

Lysolipid

0.67

0.46, 0.97

0.0347

 

Nucleotide

0.73

Adenosine 3′,5′-cyclic monophosphate

Purine metabolism, adenine containing

0.56

0.34, 0.92

0.0220

 

Peptides

0.29

Threonylphenylalanine

Dipeptide

1.47

1.05, 2.06

0.0256

 

Gamma-glutamylphenylalanine

Gamma-glutamyl amino acid

0.65

0.44, 0.96

0.0315

 

Gamma-glutamylglutamine

Gamma-glutamyl amino acid

1.41

1.03, 1.94

0.0339

 

Xenobiotics

0.51

1,3-Dimethylurate

Xanthine metabolism

0.69

0.48, 0.99

0.0426

 
  1. Abbreviations: Alpha-CEHC=Alpha-carboxyethyl-hydroxychroman; CI=confidence interval; GPC=glycerophosphocholine; GPE=glycerophosphoethanolamine; OR=odds ratio.
  2. aThe odds ratio per 80th percentile increase in metabolite. On the basis of 82 case–control pairs.
  3. bAll metabolites had detectable values in >90% of the study population with the exception of alpha-CEHC glucuronide, alpha-CEHC sulfate, 1-palmitoyl-2-linolenoyl-GPC (16:0/18:3), 17alpha-hydroxypregnenolone sulfate, 2-hydroxyadipate, adenosine 3′,5′-cyclic monophosphate, and 1,3-dimethylurate (38%, 58%, 66%, 59%, 61%, 54% and 84%, respectively).
Back to article page