Table 4 NSN for one additional mammography-only detected cancer for first and subsequent screening rounds

From: Contribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis

BRCA

Age group (years)

Number of BC in study subjects

Number of screens

BC only detected by mammography

NSN for mammography to detect one BC missed by MRI

First screening round

BRCA1

All ages

45

1053

2

527

 

Age <40

19

555

2

278

 

41–50

14

304

0

NA

 

Age >50

12

194

0

NA

BRCA2

All ages

18

564

6

94

 

Age <40

10

221

4

55

 

41–50

10

204

1

204

 

Age >50

8

139

1

139

Subsequent (repeat) screening rounds

BRCA1

All ages

67

2150

3

717

 

Age <40

27

775

1

775

 

41–50

23

797

1

797

 

Age >50

17

578

1

578

BRCA2

All ages

54

1155

5

231

 

Age <40

8

281

2

141

 

41–50

27

444

2

222

 

Age >50

9

430

1

430

  1. Abbreviations: BC=breast cancer; MRI=magnetic resonance imaging; NA=not applicable; NSN=number of screens needed.
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