Table 3 Multivariable Cox proportional hazards models of uric acid, individual NCCN-IPI items, and serum creatinine for the prediction of overall and PFS in patients with DLBCL (n=539)
Multivariable analysis OS | Multivariable analysis PFS | |||
|---|---|---|---|---|
Variable | HR (95% CI) | P -value | HR (95% CI) | P -value |
Uric acid (per 1 log increase) | 1.54 (1.07–2.22) | 0.020 | 1.45 (1.05–2.01) | 0.025 |
Age category | ||||
⩽40 years | 1 (ref.) | – | 1 (ref.) | – |
41–60 years | 1.97 (0.56–6.88) | 0.289 | 1.43 (0.64–3.18) | 0.385 |
61–75 years | 3.98 (1.24–12.74) | 0.020 | 2.10 (1.01–4.36) | 0.048 |
>75 years | 9.31 (2.90–29.95) | <0.0001 | 3.64 (1.73–7.68) | 0.001 |
Site | ||||
No extranodal disease | 1 (ref.) | – | 1 (ref.) | – |
Extranodal disease | 1.21 (0.88–1.65) | 0.242 | 1.16 (0.87–1.54) | 0.317 |
LDH ratio | ||||
<ULN | 1 (ref.) | – | 1 (ref.) | – |
1–3 × ULN | 1.22 (0.85–1.75) | 0.286 | 1.26 (0.91–1.75) | 0.157 |
>3 × ULN | 1.87 (1.15–3.03) | 0.011 | 1.93 (1.23–3.02) | 0.004 |
Clinical stage (Ann Arbor) | ||||
I&II | 1 (ref.) | – | 1 (ref.) | – |
III&IV | 1.78 (1.27–2.48) | 0.001 | 1.55 (1.15–2.09) | 0.004 |
ECOG PS | ||||
0–2 | 1 (ref.) | – | 1 (ref.) | – |
⩾2 | 1.46 (1.00–2.12) | 0.049 | 1.40 (0.98–1.99) | 0.065 |
Serum creatinine (per 1 mg dl−1 increase) | 1.04 (0.89–1.21) | 0.643 | 1.00 (0.85–1.17) | 0.951 |
