Table 2 Median survival in the cohorts according to ALBI grade within each treatment
Treatment | Cohort | ALBI grade | N | Median survival in months (95% CI) | 5-year survival, % (95% CI) | Hazard ratio (95% CI), P -value |
|---|---|---|---|---|---|---|
All patients undergoing | All | 1 | 1124 | 106.3 (96.3, 122.7) | 68.4 (65.0, 71.5) | 1 |
resection and ablative treatments | 2 | 983 | 53.7 (48.2, 58.6) | 44.7 (40.9, 48.4) | 2.0 (1.8, 2.3), P<0.0001 | |
3 | 71 | 26.9 (20.4, 33.4) | 11.1 (4.3, 21.6) | 5.0 (3.8, 6.7), P<0.0001 | ||
Patients undergoing resection | Japan | 1 | 325 | 122.7 (96.3, 148.7) | 74.6 (68.5, 79.7) | 1 |
(Child, Pugh A) | 2 | 211 | 71.2 (56.2, 82.4) | 56.1 (48.1, 63.3) | 1.9 (1.5, 2.5), P<0.0001 | |
Hong Kong | 1 | 359 | Not reached | 72.8 (66.5, 78.0) | 1 | |
2 | 91 | 44.5 (28.6) | 48.6 (34.9, 61.1) | 2.4 (1.6, 3.7), P<0.0001 | ||
Europe | 1 | 123 | 71.1 (59.0, 120.4) | 60.0 (48.3, 69.8) | 1 | |
2 | 39 | 42.3 (25.0, 69.5) | 35.1 (16.9, 54.0) | 1.7 (1.0, 2.9), P=0.05 | ||
Patients undergoing RFA | Japan | 1 | 65 | 84.2 (63.8) | 67.0 (51.5, 78.5) | 1 |
2 | 189 | 56.1 (48.6, 72.4) | 48.0 (38.7, 56.7) | 1.7 (1.1, 2.6), P=0.024 | ||
3 | 13 | 23.8 (10.1) | 0% | 5.1 (2.2, 11.7), P<0.0001 | ||
Hong Kong | 1 | 141 | 89.3 (66.7, 115.8) | 61.6 (51.2, 70.5) | 1 | |
2 | 129 | 59.2 (47.2, 64.1) | 45.7 (34.7, 56.1) | 1.7 (1.1, 2.4), P=0.003 | ||
3 | 5 | 7.4 (2.3) | 0% | 9.4 (3.3, 26.6), P<0.0001 | ||
Europe | 1 | 61 | 56.5 (36.0, 69.2) | 43.7 (27.4, 58.9) | 1 | |
2 | 89 | 30.2 (27.4, 34.3) | 16.2 (8.4, 26.1) | 2.0 (1.3, 3.0), P=0.002 | ||
3 | 12 | 19.3 (7.8, 34.2) | 13.8 (0.8, 44.3) | 2.9 (1.4, 6.2), P=0.005 |
