Table 3 HRs (95% CI) for CRC and subsites by quintiles (Q) of PC1 score and for 1 s.d. increase in PC1 score

	Q1	Q2	Q3	Q4	Q5	P -trend	HR (95% CI) per 1 s.d. increase	P -value HR continuous for 1 s.d. increase
Colorectum
N cases	1133	949	916	812	707
Basic^a	1.00 (Ref)	0.97 (0.89–1.07)	1.00 (0.9–1.10)	0.92 (0.83–1.02)	0.95 (0.84–1.06)	0.261	0.96 (0.93–1.00)	0.061
Multivariable^b	1.00 (Ref)	0.99 (0.90–1.08)	1.02 (0.92–1.12)	0.94 (0.85–1.05)	0.98 (0.88–1.11)	0.686	0.98 (0.94–1.02)	0.264
Colon
N cases	691	598	581	517	482
Basic^a	1.00 (Ref)	0.96 (0.86–1.08)	0.96 (0.85–1.08)	0.87 (0.76–0.99)	0.95 (0.82–1.10)	0.304	0.96 (0.91–1.01)	0.093
Multivariable^b	1.00 (Ref)	0.97 (0.86–1.09)	0.97 (0.86–1.10)	0.89 (0.78–1.01)	0.98 (0.85–1.13)	0.558	0.97 (0.92–1.02)	0.223
Colon, proximal
N cases	324	269	253	241	211
Basic^a	1.00 (Ref)	0.94 (0.80–1.12)	0.92 (0.76–1.10)	0.90 (0.74–1.09)	1.00 (0.80–1.24)	0.971	1.00 (0.93–1.08)	0.979
Multivariable^b	1.00 (Ref)	0.96 (0.81–1.14)	0.94 (0.78–1.13)	0.93 (0.77–1.13)	1.04 (0.84–1.29)	0.692	1.02 (0.95–1.10)	0.631
Colon, distal
N cases	320	265	263	218	200
Basic^a	1.00 (Ref)	0.92 (0.78–1.09)	0.95 (0.79–1.13)	0.80 (0.66–0.98)	0.90 (0.72–1.12)	0.168	0.92 (0.86–0.99)	0.0308
Multivariable^b	1.00 (Ref)	0.92 (0.78–1.09)	0.95 (0.79–1.14)	0.81 (0.66–0.99)	0.91 (0.74–1.14)	0.226	0.93 (0.86–1.00)	0.05
Rectum
N cases	442	351	335	295	225
Basic^a	1.00 (Ref)	1.00 (0.86–1.15)	1.06 (0.91–1.24)	1.01 (0.85–1.20)	0.92 (0.76–1.13)	0.616	0.97 (0.91–1.04)	0.376
Multivariable^b	1.00 (Ref)	1.02 (0.88–1.18)	1.10 (0.93–1.28)	1.05 (0.89–1.25)	0.98 (0.80–1.19)	0.927	0.99 (0.93–1.06)	0.799

Abbreviations: CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; PC=principal component; Ref=reference.
^aBasic model: Cox regression adjusted for total energy intake (log-transformed continuous variable) and for each score, and stratified by age (1-year categories), sex and centre.
^bMultivariable model: Cox regression adjusted for total energy intake (log-transformed continuous variable), alcohol (log-transformed continuous variable), smoking status (never, former, smoker, unknown), height (tertiles), weight (tertiles), physical activity level (inactive, moderately inactive, moderately active, active, missing) and for each score, and stratified by age (1-year categories), sex and centre.

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