Table 5 HRs (95% CI) for CRC and subsites by quintiles (Q) of PC3 score and for 1s.d. increase in PC3 score

From: Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

 

Q1

Q2

Q3

Q4

Q5

P -trend

HR (95% CI) per 1 s.d. increase

P -value HR continuous for 1 s.d. increase

Colorectum

N cases

790

899

937

1003

888

   

Basica

1.00 (Ref)

1.03 (0.94–1.14)

1.02 (0.92–1.13)

1.07 (0.97–1.19)

0.99 (0.89–1.12)

0.920

1.00 (0.97–1.04)

0.817

Multivariableb

1.00 (Ref)

1.03 (0.93–1.13)

1.01 (0.91–1.12)

1.06 (0.96–1.18)

0.98 (0.88–1.10)

0.935

1.00 (0.96–1.04)

0.99

Colon

N cases

523

553

606

644

543

   

Basica

1.00 (Ref)

0.99 (0.88–1.12)

1.04 (0.92–1.18)

1.09 (0.95–1.24)

0.95 (0.83–1.10)

0.854

0.98 (0.95–1.04)

0.722

Multivariableb

1.00 (Ref)

0.98 (0.87–1.12)

1.04 (0.91–1.18)

1.08 (0.95–1.23)

0.94 (0.82–1.09)

0.762

0.99 (0.94–1.04)

0.608

Colon, proximal

N cases

199

258

271

314

256

   

Basica

1.00 (Ref)

1.16 (0.96–1.40)

1.12 (0.92–1.36)

1.23 (1.01–1.50)

1.05 (0.84–1.30)

0.626

0.99 (0.92–1.06)

0.752

Multivariableb

1.00 (Ref)

1.15 (0.95–1.40)

1.12 (0.92–1.36)

1.23 (1.00–1.50)

1.05 (0.84–1.31)

0.594

0.99 (0.92–1.06)

0.771

Colon, distal

N cases

241

234

276

273

242

   

Basica

1.00 (Ref)

0.92 (0.77–1.11)

1.04 (0.87–1.26)

1.05 (0.86–1.27)

0.95 (0.77–1.18)

0.941

1.01 (0.94–1.08)

0.849

Multivariableb

1.00 (Ref)

0.91 (0.76–1.10)

1.03 (0.86–1.24)

1.02 (0.84–1.25)

0.93 (0.75–1.15)

0.768

1.00 (0.93–1.07)

0.94

Rectum

N cases

267

346

331

359

345

   

Basica

1.00 (Ref)

1.11 (0.94–1.31)

0.98 (0.83–1.17)

1.05 (0.89–1.29)

1.07 (0.89–1.29)

0.681

1.03 (0.96–1.09)

0.40

Multivariableb

1.00 (Ref)

1.10 (0.94–1.30)

0.97 (0.82–1.16)

1.04 (0.87–1.24)

1.05 (0.87–1.27)

0.799

1.02 (0.96–1.09)

0.515

  1. Abbreviations: CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; PC=principal component; Ref=reference.
  2. aBasic model: Cox regression adjusted for total energy intake (log-transformed continuous variable) and for each score, and stratified by age (1-year categories), sex and centre.
  3. bMultivariable model: Cox regression adjusted for total energy intake (log-transformed continuous variable), alcohol (log-transformed continuous variable), smoking status (never, former, smoker, unknown), height (tertiles), weight (tertiles), physical activity level (inactive, moderately inactive, moderately active, active, missing) and for each score, and stratified by age (1-year categories), sex and centre.
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