Table 6 HRs (95% CI) for CRC and subsites by quintiles (Q) of PC4 score and for 1 s.d. increase in PC4 score

	Q1	Q2	Q3	Q4	Q5	P -trend	HR (95% CI) per 1 s.d. increase	P -value HR continuous for 1 s.d. increase
Colorectum
N cases	831	860	923	931	972
Basic^a	1.00 (Ref)	0.97 (0.88–1.07)	0.99 (0.90–1.09)	0.94 (0.85–1.03)	0.94 (0.85–1.04)	0.172	0.98 (0.94–1.01)	0.155
Multivariable^b	1.00 (Ref)	0.96 (0.87–1.05)	0.96 (0.88–1.06)	0.91 (0.82–1.00)	0.90 (0.81–0.99)	0.0192	0.96 (0.93–0.99)	0.015
Colon
N cases	517	563	591	587	611
Basic^a	1.00 (Ref)	1.01 (0.89–1.14)	0.99 (0.88–1.12)	0.92 (0.82–1.04)	0.92 (0.81–1.04)	0.076	0.97 (0.93–1.01)	0.12
Multivariable^b	1.00 (Ref)	0.99 (0.88–1.12)	0.97 (0.86–1.10)	0.89 (0.79–1.01)	0.88 (0.77–1.00)	0.013	0.95 (0.91–0.99)	0.022
Colon, proximal
N cases	263	252	259	254	270
Basic^a	1.00 (Ref)	0.91 (0.77–1.09)	0.89 (0.75–1.07)	0.82 (0.68–0.98)	0.84 (0.70–1.01)	0.04	0.95 (0.89–1.01)	0.08
Multivariable^b	1.00 (Ref)	0.91 (0.76–1.08)	0.88 (0.74–1.05)	0.80 (0.67–0.98)	0.81 (0.67–0.98)	0.014	0.93 (0.88–0.99)	0.03
Colon, distal
N cases	209	243	275	259	280
Basic^a	1.00 (Ref)	1.06 (0.88–1.28)	1.10 (0.91–1.32)	0.95 (0.78–1.15)	0.95 (0.78–1.16)	0.33	0.97 (0.91–1.03)	0.362
Multivariable^b	1.00 (Ref)	1.03 (0.86–1.25)	1.06 (0.88–1.28)	0.91 (0.75–1.10)	0.90 (0.74–1.09)	0.115	0.95 (0.89–1.01)	0.125
Rectum
N cases	314	297	332	344	361
Basic^a	1.00 (Ref)	0.91 (0.78–1.07)	0.98 (0.84–1.15)	0.96 (0.82–1.13)	0.99 (0.84–1.16)	0.94	0.99 (0.94–1.05)	0.76
Multivariable^b	1.00 (Ref)	0.89 (0.76–1.05)	0.95 (0.81–1.12)	0.93 (0.79–1.09)	0.93 (0.79–1.10)	0.531	0.97 (0.92–1.03)	0.307

Abbreviations: CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; PC=principal component; Ref=reference.
^aBasic model: Cox regression adjusted for total energy intake (log-transformed continuous variable) and for each score, and stratified by age (1-year categories), sex and centre.
^bMultivariable model: Cox regression adjusted for total energy intake (log-transformed continuous variable), alcohol (log-transformed continuous variable), smoking status (never, former, smoker, unknown), height (tertiles), weight (tertiles), physical activity level (inactive, moderately inactive, moderately active, active, missing) and for each score, and stratified by age (1-year categories), sex and centre.

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