Table 2 Models of exposures in relation to EA-prior BE compared with EA-no prior BE

From: Pathogenesis and progression of oesophageal adenocarcinoma varies by prior diagnosis of Barrett’s oesophagus

    

Multivariable logistic regression b

Variable

EA-prior BE ( n=662)

EA-no prior BE ( n=4609)

Univariate P -value a

OR (95%CI)

P -value

GERD, %

68

15

<0.0001

11.54 (9.58, 13.90)

<0.0001

Ever cigarette smoker, %

12.2

8.2

0.001

1.31 (1.00, 1.71)

0.05

Metabolic syndrome, %

25

21

0.02

1.10 (0.90, 1.34)

0.37

Obesity, %

4.2

4.1

0.90

0.91 (0.60, 1.38)

0.66

Hypertension, %

79

66

<0.0001

1.65 (1.34, 2.03)

<0.0001

Impaired fasting glucose, %

31

28

0.07

1.07 (0.89, 1.28)

0.48

Diabetes, %

30

27

0.17

1.02 (0.85, 1.23)

0.80

Dyslipidemia, %

66

55

<0.0001

1.39 (1.17, 1.67)

0.0003

Weight loss, %

9.1

4.1

<0.0001

2.14 (1.57, 2.92)

<0.0001

Peptic ulcer, %

11.9

3.1

<0.0001

3.72 (2.75, 5.03)

<0.0001

Irritable bowel disease, %

5.6

2.6

<0.0001

1.92 (1.30, 2.82)

0.001

  1. Abbreviations: BE=Barrett’s oesophagus; CI=confidence interval; EA=oesophageal adenocarcinoma; OR=odds ratio; SEER=Surveillance, Epidemiology and End Results.
  2. aP-values were estimated from χ2-tests for categorical variables and from t-tests for continuous variables.
  3. bMultivariable logistic regression models were adjusted for age at diagnosis, sex, race, education, SEER registry and modified Charlson comorbidity score. Bolded statistics indicate P<0.05.
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