Table 3 Adverse events associated with DCF-ICT (CTCAE ver 4.0)

From: Phase II study of chemoselection with docetaxel plus cisplatin and 5-fluorouracil induction chemotherapy and subsequent conversion surgery for locally advanced unresectable oesophageal cancer

 

Grade 1, n (%)

Grade 2, n (%)

Grade 3, n (%)

Grade 4, n (%)

All, n (%)

Anorexia

10 (20.8)

13 (27.1)

12 (25.0)

0

35 (72.9)

Fatigue

22 (45.8)

9 (18.8)

1 (2.1)

0

32 (66.7)

Nausea

19 (39.6)

10 (20.8)

2 (4.2)

0

31 (64.6)

Diarrhoea

5 (10.4)

9 (18.8)

5 (10.4)

0

19 (39.6)

Mucositis oral

12 (25.0)

6 (12.5)

0

0

18 (37.5)

Dysphagia

7 (14.6)

4 (8.3)

2 (4.2)

0

13 (27.1)

Febrile neutropenia

11 (22.9)

0

11 (22.9)

Vomiting

8 (16.7)

1 (2.1)

0

0

9 (18.8)

Oesophageal fistula

0

0

2 (4.2)

0

2 (4.2)

White blood cell decreased

4 (8.3)

14 (29.2)

15 (31.3)

5 (10.4)

38 (79.2)

Neutrophil count decreased

1 (2.1)

7 (14.6)

10 (20.8)

22 (45.8)

40 (83.3)

Anaemia

29 (60.4)

14 (29.2)

0

0

43 (89.6)

Platelet count decreased

12 (25.0)

1 (2.1)

0

1 (2.1)

14 (29.2)

Aspartate aminotransferase increased

17 (35.4)

0

0

0

17 (35.4)

Alanine aminotransferase increased

15 (31.3)

2 (4.2)

1 (2.1)

0

18 (37.5)

Creatinine increased

11 (22.9)

3 (6.3)

0

0

14 (29.2)

Hyponatremia

22 (45.8)

0

6 (12.5)

1 (2.1)

29 (60.4)

  1. Abbreviations: CTCAE=Common Terminology Criteria of Adverse Events; DCF-ICT=docetaxel plus cisplatin and 5-fluorouracil induction chemotherapy.