Table 2 HRs and 95% CIs for the associations of height (per 10 cm increase) with SCC and BCC risk

From: Height, height-related SNPs, and risk of non-melanoma skin cancer

 

NHS (Female)

HPFS (Male)

Meta-analysis

 

HR (95% CI)

P -value

HR (95% CI)

P -value

HR (95% CI)

P -value

P for Heterogeneity

SCC

Model 1

1.18 (1.09, 1.28)

<0.0001

1.18 (1.08, 1.28)

<0.0001

1.18 (1.11, 1.25)

<0.0001

0.99

Model 2

1.14 (1.06, 1.24)

0.0009

1.16 (1.07, 1.26)

0.0006

1.15 (1.09, 1.22)

<0.0001

0.80

Model 3

1.10 (1.02, 1.19)

0.0198

1.10 (1.01, 1.21)

0.0215

1.10 (1.04, 1.17)

0.0011

0.92

Model 4

1.09 (1.00, 1.18)

0.0429

1.09 (1.00, 1.18)

0.0593

1.09 (1.02, 1.15)

0.0057

0.99

BCC

Model 1

1.18 (1.15, 1.20)

<0.0001

1.14 (1.11, 1.18)

<0.0001

1.16 (1.13, 1.20)

<0.0001

0.10

Model 2

1.16 (1.13, 1.18)

<0.0001

1.13 (1.09, 1.16)

<0.0001

1.14 (1.12, 1.18)

<0.0001

0.16

Model 3

1.12 (1.10, 1.15)

<0.0001

1.10 (1.07, 1.13)

<0.0001

1.11 (1.09, 1.13)

<0.0001

0.28

Model 4

1.11 (1.09, 1.14)

<0.0001

1.08 (1.05, 1.12)

<0.0001

1.10 (1.07, 1.13)

<0.0001

0.20

  1. Abbreviations: BCC=basal cell carcinoma; CI=confidence interval; HPFS=Health Professionals Follow-up Study; HR=hazard ratio; NHS=Nurses’ Health Study; PMH=postmenopausal hormone use; SCC=squamous cell carcinoma.
  2. (a) Model 1, age-adjusted.
  3. (b) Model 2 adjusted for age, smoking status (never, past, current 1–14, 15–24, or 25+ cigarettes/day), alcohol intake (no, <5.0, 5.0–9.9, 10.0–19.9, or 20.0+ g per day), body mass index (<25.0, 25.0–29.9, 30.0–34.9, or 35.0+ kg m−2), physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9 or 27.0+ metabolic equivalent hours per week), menopausal status/postmenopausal hormones use (premenopausal, PMH never, PMH past, or PMH current; only in the NHS).
  4. (c) Model 3 adjusted for covariates in Model 2, plus natural hair colour (red, blonde, light brown, dark brown, or black), childhood/adolescent sunburn reaction (none or some redness, burn, painful burn or blisters), family history of melanoma (yes or no), number of severe sunburns over life time (never, 1–2 times, 3–5 times, or 6+ times), mole count (none, 1–2, 3–9, 10+), and states lived at birth, age 15, and age 30 (UV index ⩽5, =6, or ⩾7).
  5. (d) Model 4 adjusted for covariates in Model 3 and race (Southern European/Mediterranean, Scandinavian, other Caucasian, or other race group).
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